In the field of chemical synthesis, specific molecules serve as foundational components for creating a vast array of complex compounds. Trans-N-Boc-1,4-Cyclohexanediamine (CAS 177906-48-8) is one such indispensable intermediate, playing a significant role in both pharmaceutical development and advanced organic chemistry.

This compound, chemically known as tert-butyl ((1r,4r)-4-aminocyclohexyl)carbamate, is a white solid with the molecular formula C11H22N2O2 and a molecular weight of approximately 214.30 g/mol. Its structure is characterized by a cyclohexane ring with two amine groups in a trans configuration at positions 1 and 4. Crucially, one of these amine groups is protected by a tert-butyloxycarbonyl (Boc) group. This Boc protection is a common strategy in organic synthesis, allowing for selective reactions at the unprotected amine group or later deprotection to reveal the protected amine for further functionalization. This versatility makes it highly sought after by researchers and manufacturers.

The primary application of Trans-N-Boc-1,4-Cyclohexanediamine is as a pharmaceutical intermediate. Its structure can be incorporated into the synthesis of various drug candidates, contributing to the development of new medicines. For instance, it has been used in the preparation of selective V1A receptor antagonists, which are being investigated for therapeutic potential in conditions like hyponatremia. The trans stereochemistry and the presence of the diamine functionality make it a valuable chiral building block, essential for creating stereochemically defined molecules often required for drug efficacy and safety.

Beyond its pharmaceutical roles, Trans-N-Boc-1,4-Cyclohexanediamine is also a valuable reagent in broader organic synthesis. It can be employed as a linker in the construction of more complex molecular architectures, including those used in materials science or as ligands for catalysis. The ability to purchase this compound from reliable manufacturers, especially from China, offers an excellent opportunity for businesses to secure a cost-effective and consistent supply. When looking to buy, consider suppliers that offer high purity (e.g., ≥95% or ≥97% purity by GC) and provide detailed technical documentation.

For procurement managers and R&D scientists, understanding the specifications and applications of such intermediates is key to efficient sourcing. It is important to partner with suppliers who prioritize quality control and can provide consistent product batches. Manufacturers committed to rigorous quality assurance processes ensure that the Trans-N-Boc-1,4-Cyclohexanediamine you purchase will perform as expected in your synthetic processes. Engaging with suppliers that offer competitive pricing, especially for bulk quantities, is a strategic move for managing project costs.

In conclusion, Trans-N-Boc-1,4-Cyclohexanediamine stands out as a critical intermediate in chemical synthesis, particularly for the pharmaceutical industry. Its unique protected diamine structure and trans configuration make it an ideal building block for complex molecules. By identifying and partnering with reputable manufacturers and suppliers, particularly those based in China, researchers and manufacturers can ensure a reliable and cost-effective supply of this essential chemical.