Innovation in drug delivery is transforming how we treat diseases, making therapies more accessible and effective. Salcaprozate Sodium, commonly known as SNAC, is a prime example of such innovation. As a potent intestinal permeation enhancer, SNAC plays a crucial role in enabling the oral administration of macromolecules—drugs that were previously limited to injectable formulations.

At our company, we are dedicated to supplying high-quality pharmaceutical ingredients, and SNAC is a cornerstone of our offerings. As a leading manufacturer and supplier, we understand the significance of this compound in modern drug development. Our 8-[(2-hydroxybenzoyl)amino]octanoic acid (the free acid form), CAS 183990-46-7, and its sodium salt are produced with the utmost attention to purity and consistency, meeting the rigorous demands of the pharmaceutical sector.

The Science Behind SNAC's Efficacy

SNAC's primary function is to enhance the oral absorption of drugs that exhibit poor bioavailability. This is particularly important for large molecules like peptides and proteins, which are susceptible to degradation in the gastrointestinal tract and have difficulty crossing the intestinal barrier. SNAC achieves this through several sophisticated mechanisms:

  • Protection and pH Modulation: In the stomach, SNAC creates a localized increase in pH, shielding sensitive peptide drugs from enzymatic degradation by pepsin.
  • Membrane Permeation: It interacts with the intestinal lining, temporarily increasing the permeability of the epithelial cells. This allows for enhanced passive absorption of the drug through a transcellular route.
  • Solubility Enhancement: SNAC can also improve the solubility of co-administered drugs, further aiding their absorption.

These synergistic actions enable the development of oral dosage forms for drugs that were once exclusively administered via injection, offering significant benefits in patient convenience and compliance.

Applications and Our Commitment as a Supplier

The impact of SNAC is most evident in the field of oral peptide therapeutics, most notably in the development of oral semaglutide for type 2 diabetes. This breakthrough has paved the way for similar advancements in other therapeutic areas.

For pharmaceutical companies looking to leverage these advancements, securing a reliable supply of high-purity SNAC is essential. As an established manufacturer and supplier, we guarantee:

  • Uncompromised Purity: Our 8-[(2-hydroxybenzoyl)amino]octanoic acid and its sodium salt meet stringent pharmaceutical-grade specifications.
  • Consistent Supply Chain: We ensure dependable availability to support your research and manufacturing timelines.
  • Competitive Pricing: We offer attractive pricing for bulk quantities, making advanced drug delivery solutions more accessible.

The ability to deliver complex biological drugs orally represents a significant leap forward in patient care. Our commitment as a supplier of SNAC is to empower this innovation. We invite researchers and developers to contact us to learn more about our products and to discuss how we can support your formulation needs. Buy high-quality SNAC from a trusted source to advance your drug development goals.