Calcium Folinate, chemically known as folinic acid or leucovorin calcium, is a crucial synthetic derivative of folic acid. Its importance spans critical areas of medicine, primarily in oncology as a rescue agent for Methotrexate chemotherapy and in hematology for treating specific types of anemia. Understanding the scientific underpinnings of its action and effective sourcing strategies is vital for procurement and R&D professionals in the life sciences industry.

The therapeutic action of Calcium Folinate is deeply rooted in folate metabolism. Folic acid itself is a precursor to tetrahydrofolate (THF), a coenzyme essential for the synthesis of purines and pyrimidines, the building blocks of DNA and RNA. Methotrexate, a potent antifolate drug, inhibits dihydrofolate reductase (DHFR), the enzyme that converts dihydrofolate to THF. This inhibition halts DNA synthesis, particularly in rapidly dividing cells, which is the basis of its cytotoxic effect against cancer. However, it also affects healthy cells. Calcium Folinate, being a formylated derivative of THF, enters the folate pathway downstream of DHFR, thus bypassing the Methotrexate-induced block. This allows normal cells to continue their essential DNA synthesis, a process known as 'folinic acid rescue' or 'Leucovorin rescue'. This application is fundamental in high-dose Methotrexate regimens used for osteosarcoma, leukemia, and lymphoma.

Beyond cancer therapy, Calcium Folinate serves as a treatment for megaloblastic anemias resulting from folate deficiency, particularly when folate absorption is impaired or dietary intake is insufficient. By providing a ready source of reduced folates, it corrects the metabolic defect leading to macrocytic anemia. The quality and bioavailability of folinic acid calcium are key factors for its therapeutic efficacy.

For professionals seeking to buy Calcium Folinate (CAS 1492-18-8), identifying a reliable pharmaceutical intermediate supplier in China is a strategic imperative. We offer Calcium Folinate with assured high purity (typically 98%), ensuring it meets the rigorous standards required for pharmaceutical manufacturing and medical research. Our role as a proactive manufacturer in China allows us to maintain consistent quality and availability, making us a preferred source for this essential chemical.

The efficacy of Calcium Folinate is also leveraged in combination therapies, most notably with 5-Fluorouracil (5-FU) in treating advanced colorectal cancer. This combination therapy potentiates the action of 5-FU by stabilizing its interaction with thymidylate synthase. Consequently, there is a continuous demand for high-quality folinic acid for these critical applications. Inquiries regarding Calcium Folinate price for bulk procurement are common, reflecting its widespread use.

To effectively source this compound, buyers should look for suppliers who provide detailed Certificates of Analysis (CoA), adhere to Good Manufacturing Practices (GMP), and have a proven track record in international trade. We are committed to being a transparent and dependable pharmaceutical raw material supplier, facilitating seamless procurement of folinic acid in bulk or as a specific CAS 1492-18-8 chemical.

In essence, Calcium Folinate is a scientifically vital compound with profound implications in managing chemotherapy side effects and treating anemias. By prioritizing quality and partnering with experienced suppliers, organizations can ensure they have access to this critical pharmaceutical chemical, supporting advancements in patient care and medical research.