Calcium Folinate, also known as Leucovorin, is a cornerstone compound in modern medicine, serving two critical functions: as a vital rescue agent in specific cancer chemotherapy regimens and as a treatment for certain types of anemia. Its chemical nature as a metabolically active form of folic acid allows it to play an indispensable role in cellular processes, making it a high-demand pharmaceutical intermediate. For professionals in the pharmaceutical and medical research sectors, understanding its applications and securing a reliable supply is paramount.

In oncology, Calcium Folinate is most famously used to mitigate the toxicity of Methotrexate, a powerful antifolate chemotherapy drug. Methotrexate inhibits dihydrofolate reductase (DHFR), an enzyme essential for DNA synthesis. However, this inhibition can lead to severe side effects affecting healthy, rapidly dividing cells. Calcium Folinate, being a reduced form of folic acid, bypasses the DHFR blockade, effectively 'rescuing' normal cells by replenishing their folate pool. This 'Leucovorin rescue' is critical in high-dose Methotrexate protocols, which are employed in treating various cancers such as osteosarcoma, choriocarcinoma, and certain lymphomas. The need for high-purity calcium folinate as a chemotherapy adjuvant is consistently high.

Moreover, Calcium Folinate plays a key role in combination therapies, particularly with Fluorouracil (5-FU) for advanced colorectal cancer. By stabilizing the binding of 5-FU to thymidylate synthase, it enhances the drug's cytotoxic effect, improving treatment efficacy and patient prognosis. This application further solidifies Calcium Folinate's position as a critical pharmaceutical intermediate. Sourcing from a reputable pharmaceutical intermediate supplier ensures the quality needed for these complex medical treatments.

Separately, Calcium Folinate is an effective treatment for megaloblastic anemia caused by folate deficiency, especially when patients cannot tolerate oral medication or suffer from malabsorption syndromes. It directly addresses the underlying folate deficit, promoting the production of healthy red blood cells. The reliability of folinic acid calcium as a treatment option makes it a staple in many medical formularies.

For organizations looking to buy Calcium Folinate (CAS 1492-18-8), partnering with a trusted manufacturer in China is a strategic decision. We are dedicated to providing premium quality Calcium Folinate, meeting stringent purity standards required for pharmaceutical use. Our commitment extends to offering competitive Calcium Folinate price points and ensuring a stable supply chain for clients worldwide. Whether you are researching new therapeutic avenues or fulfilling established treatment protocols, we are equipped to meet your demands for folinic acid in bulk.

In summary, Calcium Folinate's dual utility in managing chemotherapy side effects and treating anemia makes it an invaluable pharmaceutical compound. As a leading pharmaceutical raw material supplier, we understand the critical importance of quality and reliability. We invite you to explore our offerings and secure your supply of high-grade Calcium Folinate to support vital medical applications.