Protein Arginine Deiminase 4 (PAD4) is a key enzyme in biological pathways that, when dysregulated, contributes to various diseases, notably inflammatory and autoimmune conditions. To effectively study these complex mechanisms, researchers rely on highly specific and potent inhibitors. GSK484, a well-characterized compound with CAS number 1652591-81-5, serves as an invaluable tool for this purpose, offering a precise means to explore PAD4's function and its implications.

At its core, GSK484 is designed to inhibit PAD4, an enzyme critical for the process of citrullination. Citrullination involves the conversion of the amino acid arginine into citrulline. While this modification has normal physiological roles, its dysregulation, particularly through excessive PAD4 activity, is strongly implicated in diseases like rheumatoid arthritis, where it contributes to autoimmune responses. GSK484 precisely targets this enzymatic activity, offering researchers a way to modulate these pathways in experimental settings.

A significant aspect of GSK484's scientific value lies in its selectivity. It exhibits a high degree of specificity for PAD4, differentiating it from other members of the PAD family (PAD1, PAD2, PAD3). This selectivity is crucial for accurate research outcomes, allowing scientists to pinpoint the effects of PAD4 inhibition without interference from the actions of other PAD isoforms. This precision is vital when studying complex biological systems where multiple enzymes might be present.

Beyond general protein citrullination, GSK484 is also known for its ability to inhibit the formation of Neutrophil Extracellular Traps (NETs). NETs are a component of the innate immune system, but their overproduction can lead to tissue damage and exacerbate inflammatory conditions. By inhibiting NET formation, GSK484 provides researchers with a direct means to investigate the role of this process in both health and disease. This makes it a powerful tool for understanding immune responses and developing targeted therapies.

For researchers aiming to buy GSK484 and integrate it into their studies, securing a reliable supply is essential. As a leading supplier in China, we provide GSK484 hydrochloride (GSK484 HCl) with guaranteed high purity, ensuring that your experiments yield accurate and reproducible results. Understanding the price and availability from a reputable manufacturer allows for effective planning and budgeting of research projects. When you purchase GSK484, you are investing in a crucial element for advancing your understanding of PAD4-related mechanisms.

The detailed scientific literature on GSK484 underscores its importance in the field. Its application spans from basic biochemical assays to complex cellular models, all aimed at unraveling the role of PAD4. We invite you to contact us for more information on how to procure this vital research tool and to receive a comprehensive quote for your needs. Partner with a trusted source to fuel your scientific breakthroughs.