In the complex landscape of biomedical research, understanding specific enzyme functions and their impact on disease is paramount. Protein Arginine Deiminase 4 (PAD4) is one such enzyme that has garnered significant attention due to its critical roles in inflammatory processes and autoimmune diseases, particularly rheumatoid arthritis. Researchers seeking to delve into these mechanisms often require precise chemical tools, and GSK484 stands out as a powerful option.

GSK484, identified by its CAS number 1652591-81-5, is a highly potent and selective inhibitor of PAD4. Its primary function is to block the enzymatic activity of PAD4, which is responsible for converting arginine residues in proteins into citrulline. This process, known as citrullination, is implicated in various biological functions, including the formation of Neutrophil Extracellular Traps (NETs). NETs are DNA-based structures released by neutrophils that play a role in host defense but can also contribute to pathological inflammation and tissue damage in conditions like rheumatoid arthritis.

The selectivity of GSK484 for PAD4 over other PAD isoforms (PAD1-3) is a crucial advantage. This specificity allows researchers to isolate and study the effects of PAD4 inhibition without confounding influences from other related enzymes. By utilizing GSK484, scientists can effectively investigate how inhibiting PAD4 impacts protein citrullination and, consequently, the development and progression of inflammatory and autoimmune conditions. This makes GSK484 an indispensable reagent for many biochemical assays and cellular studies.

For researchers looking to buy GSK484 for their investigations, sourcing from a reputable supplier in China is key to ensuring quality and reliability. Companies like NINGBO INNO PHARMCHEM CO.,LTD. offer this compound, providing researchers with access to high-purity products at competitive prices. When you purchase GSK484 hydrochloride, you are acquiring a well-characterized tool that can accelerate your understanding of disease pathways.

The availability of GSK484 as a hydrochloride salt (GSK484 HCl) further enhances its utility, often improving solubility and handling characteristics for laboratory use. Researchers can confidently incorporate this inhibitor into their experimental protocols, whether they are exploring its effects on cell culture, enzyme kinetics, or broader physiological responses. The ability to purchase GSK484 easily and affordably from trusted manufacturers directly supports the advancement of critical research in immunology and rheumatology.

In summary, GSK484 is a vital chemical probe for anyone studying the intricacies of PAD4's role in health and disease. Its potency, selectivity, and direct impact on protein citrullination and NET formation make it an essential component in the toolkit of modern biomedical researchers. We encourage you to contact us for the latest quotes and to secure your supply of this critical research chemical.