Lipidomics, the comprehensive study of lipids in biological systems, relies on the accurate identification and quantification of a vast array of lipid species. Among these, lysophospholipids like 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine (O-LysoPE) play crucial roles, making them subjects of intense scientific investigation. For researchers diving into lipidomics, cell signaling, or metabolic studies, understanding the nuances of O-LysoPE and securing a reliable supply is fundamental. This article outlines the scientific significance of O-LysoPE and highlights best practices for its acquisition.

O-LysoPE in Lipidomics Research

O-LysoPE (CAS 89576-29-4) is a naturally occurring lysophosphatidylethanolamine that is present in various biological matrices. Its presence and changes in concentration can serve as biomarkers for different physiological and pathological states. In lipidomics studies, O-LysoPE is analyzed using techniques such as Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS).

Key scientific aspects and applications include:

  • Metabolic Pathway Analysis: O-LysoPE is a breakdown product of phosphatidylethanolamine (PE) and can be synthesized through various enzymatic pathways. Studying its levels helps elucidate lipid metabolism and cellular homeostasis. For instance, its increased presence in brown adipose tissue following cold exposure suggests a role in thermogenesis.
  • Cellular Function Studies: Researchers utilize O-LysoPE to investigate signaling cascades. Its ability to induce intracellular calcium increases in neuronal cells provides insights into neurotransmission and neuronal health. This makes it a valuable probe for exploring receptor-ligand interactions and downstream signaling events.
  • Immunological Research: The modulation of cytokine production by O-LysoPE, as mentioned in scientific literature, makes it relevant for understanding immune cell activation and response mechanisms, particularly in the context of Th2 responses.

The Importance of Purity and Supplier Reliability

For accurate lipidomics and biochemical research, the purity of O-LysoPE is non-negotiable. Impurities can lead to misinterpretation of results and affect experimental reproducibility. Therefore, when you plan to buy O-LysoPE, it is imperative to source it from reputable chemical manufacturers or suppliers who:

  • Provide High-Purity Products: Ensuring >98% purity is standard for reliable research chemicals.
  • Offer Detailed Specifications: Including clear CAS numbers (89576-29-4) and analytical data like NMR and LC-MS reports.
  • Maintain Consistent Quality: Batch-to-batch consistency is crucial for long-term research projects.
  • Offer Competitive Pricing: Sourcing from manufacturers in China can often provide cost efficiencies.

By partnering with a trusted supplier for your O-LysoPE needs, you can confidently advance your lipidomics research, ensuring the integrity and accuracy of your findings. Explore the scientific frontier with high-quality biochemicals.