Cell signaling pathways are fundamental to virtually all biological processes, from cellular growth and differentiation to immune responses and neuronal activity. Lysophospholipids, as a class of bioactive lipids, play critical roles as signaling molecules. Among these, 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine (O-LysoPE) is a compound of significant interest to researchers investigating these intricate pathways. For scientists delving into cellular mechanisms, understanding the properties of O-LysoPE and sourcing it from reliable manufacturers is paramount.

The Signaling Roles of O-LysoPE

O-LysoPE, with its specific chemical structure identified by CAS 89576-29-4, is recognized for its ability to modulate cellular functions. Scientific studies have highlighted its involvement in:

  • Calcium Signaling: O-LysoPE has been demonstrated to induce transient increases in intracellular calcium levels in neuronal cells. This mechanism is crucial for processes like neurotransmitter release and synaptic plasticity, making O-LysoPE a valuable tool for neuroscientists studying neuronal communication.
  • Immune System Modulation: Research suggests that O-LysoPE can influence the production of immune cytokines, such as Interleukin-2 (IL-2) and Interleukin-4 (IL-4). This indicates a role in regulating immune cell activation and differentiation, particularly in promoting T helper 2 (Th2) responses. This makes it relevant for immunology research and the development of immunomodulatory therapies.
  • Metabolic Insights: The presence of O-LysoPE in specific metabolic tissues, like brown adipose tissue, and its response to stimuli like cold exposure, suggests its involvement in energy metabolism and thermogenesis. This opens avenues for research into metabolic disorders and energy regulation.

Sourcing High-Purity O-LysoPE for Research

For accurate and reproducible results in cell signaling research, the purity of O-LysoPE is critical. Impurities can interfere with signaling pathways or lead to misinterpretation of experimental data. Therefore, researchers and procurement specialists should prioritize:

  • Purity Standards: Opt for O-LysoPE with a purity of 98% or higher, ensuring reliable experimental outcomes. Always request a Certificate of Analysis (CoA) from the supplier.
  • Supplier Credibility: Partner with established chemical manufacturers and suppliers known for their quality control and expertise in producing fine biochemicals. Sourcing from a reputable manufacturer in China can provide access to high-quality products at competitive prices.
  • Application-Specific Data: Seek suppliers who can provide information or references related to the use of O-LysoPE in specific signaling pathways or cellular models.

By understanding the scientific importance of O-LysoPE in cell signaling and choosing a trusted supplier for your O-LysoPE needs, researchers can effectively investigate complex biological mechanisms and drive forward scientific discovery. Procuring quality biochemicals is the cornerstone of impactful research.