For pharmaceutical researchers and procurement managers, sourcing high-quality chemical intermediates is paramount to successful drug development. 2-Amino-5-methoxybenzonitrile (CAS: 23842-82-2) stands out as a critical building block in the synthesis of various active pharmaceutical ingredients (APIs) and heterocyclic compounds. Understanding its properties and reliable sourcing channels is key to efficient operations.

Understanding 2-Amino-5-methoxybenzonitrile

This organic compound, also known by synonyms like 6-Amino-m-anisonitrile or 2-Cyano-4-methoxyaniline, possesses a molecular formula of C8H8N2O and a molecular weight of approximately 148.16. Its typical appearance is a pale yellow to dark beige solid, with a reported melting point in the range of 46-47℃. The purity of this intermediate often reaches up to 98%, which is essential for reactions where impurities could significantly impact the yield or quality of the final product. Its role as a precursor in synthesizing biologically active molecules makes it indispensable in medicinal chemistry.

Key Applications in Pharmaceuticals

The versatility of 2-Amino-5-methoxybenzonitrile lies in its functional groups, allowing it to participate in a wide array of synthetic pathways. It is frequently employed in the synthesis of complex heterocyclic systems that form the core structures of many modern pharmaceuticals. These applications span various therapeutic areas, from anti-inflammatory agents to compounds targeting neurological disorders. For R&D scientists, having access to a consistent and high-purity supply of this intermediate is crucial for reproducible research outcomes and the seamless progression of drug candidates through the development pipeline.

Sourcing Strategies: Manufacturer vs. Distributor

When looking to buy 2-Amino-5-methoxybenzonitrile, understanding your supplier options is vital. While distributors can offer convenience, sourcing directly from a manufacturer, particularly in China where many chemical intermediates are produced at scale, often provides significant advantages. Direct relationships with manufacturers can lead to more competitive pricing, better control over quality assurance, and more direct communication regarding lead times and custom synthesis requirements. Purchasing from a reputable China manufacturer ensures you get a reliable supply chain for this essential pharmaceutical intermediate.

What to Look for When Purchasing

When you inquire about 2-Amino-5-methoxybenzonitrile, always ask for detailed product specifications, including purity analysis (e.g., GC or HPLC reports) and physical properties. Furthermore, inquire about packaging options, storage recommendations (often advised to keep in a dark place under an inert atmosphere at room temperature), and shipping capabilities. For bulk purchases, negotiating pricing based on quantity is standard practice. Understanding the supplier's commitment to quality control and their experience as a chemical manufacturer will provide confidence in your procurement decisions.

In conclusion, securing a reliable source for 2-Amino-5-methoxybenzonitrile is a strategic step for any pharmaceutical company focused on innovation. By prioritizing quality, understanding product specifications, and choosing experienced manufacturers, you can ensure the consistent availability of this vital intermediate for your drug development programs.