For procurement managers in the pharmaceutical industry, securing a reliable supply of high-quality intermediates is paramount. One such critical compound is 2-Cyano-Phenothiazine (CAS 38642-74-9). This article delves into why this chemical is essential and how to effectively source it from reputable manufacturers and suppliers.

Understanding 2-Cyano-Phenothiazine (CAS 38642-74-9)
2-Cyano-Phenothiazine is a white to yellow crystalline powder with a defined melting point typically around 202-203.5°C. Its molecular formula is C13H8N2S, and it is recognized for its high purity, often exceeding 98.5% assay, with common findings of 99.7%. The primary significance of this compound lies in its role as a vital pharmaceutical intermediate. It is particularly crucial in the synthesis of pericyazine, a well-known antipsychotic drug.

Why is it Important for Pharmaceutical Manufacturers?
The efficacy and safety of any Active Pharmaceutical Ingredient (API) depend heavily on the quality of its precursors. For manufacturers involved in the production of pericyazine or similar compounds, sourcing 2-Cyano-Phenothiazine with guaranteed purity and consistent quality is non-negotiable. A reliable supply chain ensures uninterrupted production and adherence to regulatory standards.

Key Considerations for Procurement:

  • Purity and Assay: Always look for suppliers that provide a detailed Certificate of Analysis (CoA) specifying the purity (assay) and impurity profiles. For 2-Cyano-Phenothiazine, an assay of ≥98.5% is standard, with higher purities being advantageous.
  • Supplier Reliability: Partnering with established chemical manufacturers and suppliers, particularly those with experience in pharmaceutical intermediates, is crucial. Companies with strong quality management systems (like ISO 9001) and transparent production processes offer greater assurance. Consider suppliers who can offer bulk quantities and have significant production capacity.
  • Pricing and Cost-Effectiveness: While quality is paramount, procurement managers must also consider pricing. Comparing quotes from multiple reputable suppliers in regions known for chemical manufacturing, such as China, can help achieve cost-effectiveness without compromising quality. Understanding the price per kilogram and potential discounts for bulk orders is essential.
  • Logistics and Delivery: Ensure the supplier can meet your delivery timelines and has experience in handling international shipments. For high-value intermediates like 2-Cyano-Phenothiazine, discussing shipping methods (air freight for urgent needs, sea freight for bulk) is important.

Where to Buy 2-Cyano-Phenothiazine: The Manufacturer Advantage
When seeking to purchase 2-Cyano-Phenothiazine, prioritizing direct relationships with manufacturers can offer significant benefits. Direct sourcing often leads to more competitive pricing, better technical support, and a more direct line of communication regarding product specifications and supply consistency. Companies that specialize in the production of organic intermediates and have a strong presence in the global market are ideal partners. For example, sourcing from experienced Chinese manufacturers ensures access to large-scale production capabilities and a competitive cost structure.

In conclusion, for pharmaceutical procurement professionals, identifying and partnering with a dependable manufacturer of 2-Cyano-Phenothiazine is a strategic imperative. By focusing on purity, supplier reliability, competitive pricing, and efficient logistics, you can ensure a smooth and cost-effective procurement process, ultimately contributing to the successful production of vital medications.