For professionals in pharmaceutical research and development, securing high-quality chemical intermediates is paramount. Among these, 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile (CAS 138564-59-7) stands out as a significant compound, particularly recognized for its role in Olanzapine synthesis and as a reference standard for Olanzapine impurity A. Understanding its properties and how to effectively source it is key to efficient drug development.

Understanding the Compound's Value

5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile is a thiophene derivative characterized by a specific arrangement of functional groups that make it a versatile intermediate in organic synthesis. Its chemical properties, including a melting point typically between 109-115°C, contribute to its handling and reactivity in synthetic processes. For pharmaceutical companies, its primary value lies in its application as an intermediate in the synthesis of Active Pharmaceutical Ingredients (APIs), and critically, as an Olanzapine impurity standard. The ability to accurately identify and quantify impurities is fundamental to meeting stringent regulatory requirements and ensuring drug safety and efficacy.

Key Applications in Pharmaceutical R&D

The utility of this compound extends across several crucial areas within the pharmaceutical industry:

  • API Synthesis: It serves as a fundamental building block in the multi-step synthesis of complex pharmaceutical molecules, contributing to the creation of new therapeutic agents.
  • Impurity Profiling: As Olanzapine impurity A, it is indispensable for quality control departments. Researchers use it to develop and validate analytical methods for detecting and quantifying impurities in finished drug products, ensuring compliance with pharmacopoeial standards.
  • Research and Development: Its unique structure also makes it a subject of interest for academic and industrial researchers exploring novel organic reactions and material science applications.

Sourcing Strategies: Finding the Right Manufacturer and Supplier

When sourcing 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile, especially for research and development purposes, several factors are critical. Prospective buyers should prioritize suppliers who can provide comprehensive documentation, including Certificates of Analysis (CoA) detailing purity and spectral data. For pharmaceutical applications, adherence to GMP (Good Manufacturing Practice) standards, where applicable, is also a significant consideration.

Partnering with a reputable manufacturer and supplier based in China can offer significant advantages. These include access to competitive pricing, particularly for bulk purchases, and a stable supply chain. Companies specializing in fine chemicals and pharmaceutical intermediates are well-equipped to meet the demands of the industry. When initiating contact, be prepared to discuss your specific needs, including desired purity levels, quantities, and delivery timelines. Asking about manufacturer capabilities and quality control processes will ensure you select a partner that aligns with your project's rigor.

Navigating the Procurement Process

For procurement managers and R&D scientists, the process of buying this intermediate involves careful consideration of technical specifications and supplier reliability. Exploring options for obtaining a quote, understanding payment terms (such as L/C, T/T, or PayPal), and clarifying Incoterms (like FOB, CFR, CIF) are essential steps. For those looking to purchase in smaller quantities for initial research, smaller suppliers may offer more flexibility. However, for larger-scale synthesis or ongoing production needs, establishing a relationship with a primary manufacturer is advisable.

In conclusion, 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile is a compound of significant importance in the pharmaceutical sector. By understanding its applications and implementing a strategic sourcing approach, research teams can secure a reliable supply of this critical intermediate, thereby accelerating their drug development pipelines. Engaging with experienced manufacturers and suppliers in China can provide both quality and economic advantages, making the procurement process more efficient.

We, as a trusted manufacturer and supplier, are dedicated to meeting your chemical sourcing needs. Explore our offerings and contact us for a competitive quote on 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile.