For procurement managers and R&D scientists in the pharmaceutical sector, securing high-quality intermediates is paramount. One such compound, 7-Chloro-2-methylquinoline (CAS 4965-33-7), plays a significant role in the synthesis of vital medications, most notably Montelukast Sodium Salt. Understanding its properties and how to source it effectively can streamline your supply chain and ensure product integrity.

Understanding 7-Chloro-2-methylquinoline's Importance

7-Chloro-2-methylquinoline, also known by synonyms like 7-Chloroquinaldine, is a quinoline derivative characterized by its molecular formula C10H8ClN and a molecular weight of 177.63 g/mol. It typically appears as a white to light beige crystalline powder with a melting point range of 74-78°C. Its primary utility lies as a key building block in the complex synthesis pathways of active pharmaceutical ingredients (APIs). Its specific chemical structure allows for targeted reactions, making it indispensable for creating molecules with therapeutic value.

The Critical Role in Montelukast Synthesis

One of the most significant applications of 7-Chloro-2-methylquinoline is its use as a starting material in the synthesis of Montelukast Sodium Salt. Montelukast is a leukotriene receptor antagonist widely prescribed for the management of asthma and allergic rhinitis. The reliable and consistent supply of high-purity 7-Chloro-2-methylquinoline is therefore directly linked to the efficient production of this crucial respiratory medication. Buyers looking to purchase this intermediate need to ensure they are working with a manufacturer that can guarantee consistent quality, as even minor variations can impact downstream synthesis yields and the purity of the final API.

Key Considerations When Buying 7-Chloro-2-methylquinoline

When sourcing 7-Chloro-2-methylquinoline, several factors are critical for pharmaceutical procurement managers:

  • Purity: Look for suppliers that can guarantee a high purity level, typically 99% or more, as verified by reliable analytical methods like GC. High purity is essential to minimize side reactions and ensure the quality of the final drug product.
  • Supplier Reliability: Partner with experienced manufacturers and suppliers who have a proven track record in producing pharmaceutical intermediates. This includes understanding their production capacity, quality control systems (e.g., ISO certifications), and ability to provide necessary documentation (like Certificates of Analysis - CoA).
  • Regulatory Compliance: Ensure that the supplier can provide necessary regulatory support and documentation that may be required for your market.
  • Price and Lead Time: Competitive pricing and predictable lead times are crucial for efficient supply chain management. It's advisable to obtain quotes from multiple reputable suppliers in China, a primary manufacturing hub for such chemicals.
  • Safety Data: Always request and review the Material Safety Data Sheet (MSDS) to understand proper handling, storage, and safety precautions.

Finding a Trusted Manufacturer in China

China is a global leader in the manufacturing of fine chemicals and pharmaceutical intermediates. Identifying a trustworthy 7-Chloro-2-methylquinoline manufacturer involves due diligence. Look for companies that emphasize quality, have robust R&D capabilities, and are transparent about their production processes. Building a relationship with a reliable supplier ensures a stable supply of this essential intermediate, supporting your production schedules and ultimately contributing to patient access to vital medicines.

In conclusion, for any pharmaceutical company requiring 7-Chloro-2-methylquinoline, prioritizing purity, supplier reliability, and competitive sourcing from established manufacturers is key. By understanding these critical aspects, procurement professionals can effectively secure this vital pharmaceutical intermediate, driving the successful development and production of life-saving drugs.