In the dynamic world of pharmaceutical manufacturing, securing a consistent and high-quality supply of key intermediates is paramount. For companies involved in the production of Alogliptin, a widely used antidiabetic medication, the intermediate 2-((6-Chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile (CAS: 865758-95-8) plays a pivotal role. Understanding the nuances of sourcing this compound is crucial for maintaining production efficiency and drug efficacy. This article aims to guide procurement managers and R&D scientists in identifying reliable manufacturers and suppliers, particularly within China, ensuring they obtain this vital component with confidence.

Understanding the Intermediate: Properties and Importance

2-((6-Chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile is a light yellow solid with a chemical formula of C12H8ClN3O2 and a molecular weight of 261.664. Its significance lies in its function as a direct precursor in the synthesis of Alogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor that helps regulate blood sugar levels in patients with type 2 diabetes. The high purity required for pharmaceutical intermediates, typically exceeding 98%, with minimal moisture and impurities, is critical. This ensures the final API meets rigorous regulatory standards. When looking to purchase this chemical, paying close attention to its specifications, such as purity, appearance, and packaging, is essential. A reputable manufacturer in China will provide detailed Certificates of Analysis (CoA) to verify these attributes.

Key Considerations When Buying from a Supplier

For pharmaceutical procurement professionals, selecting the right supplier is as critical as the quality of the intermediate itself. When you buy 2-((6-Chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile, consider the following:

  • Supplier Reputation and Experience: Look for suppliers with a proven track record in the pharmaceutical intermediates market. Companies specializing in fine chemical manufacturing often have the necessary expertise and infrastructure.
  • Quality Control and Certifications: Ensure the supplier has robust quality management systems in place. Certifications like ISO are good indicators, but also verify their ability to provide batch-specific quality documentation.
  • Production Capacity and Lead Times: Assess if the supplier can meet your required volumes and delivery schedules. For large-scale production, a reliable Alogliptin intermediate supplier must demonstrate scalability.
  • Competitive Pricing: While quality is paramount, obtaining competitive pricing from manufacturers in China can significantly impact your cost of goods sold. Requesting quotes from multiple established suppliers is advisable.
  • Technical Support: A good supplier will offer technical support, assisting with any queries regarding the product's properties, handling, or storage.

NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated manufacturer of pharmaceutical intermediates, including compounds like 2-((6-Chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile. We understand the stringent demands of the pharmaceutical industry and are committed to delivering high-purity products with exceptional reliability. Our operations in China are geared towards meeting global demand with competitive pricing and dependable service. If you are seeking to order CAS 865758-95-8 for your Alogliptin synthesis, we invite you to contact us for a quotation and to discuss your specific requirements.

In summary, the strategic sourcing of crucial pharmaceutical intermediates like 2-((6-Chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile is a cornerstone of successful API manufacturing. By partnering with experienced and quality-focused suppliers, pharmaceutical companies can ensure the integrity and efficacy of their final drug products.