The development and manufacturing of effective pharmaceuticals often hinge on the availability of highly specific chemical intermediates. For the antidiabetic drug Alogliptin, a key compound enabling its synthesis is 2-((6-Chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile, identified by CAS number 865758-95-8. This intermediate is integral to the complex organic synthesis pathways that lead to the active pharmaceutical ingredient (API). Understanding its chemical profile and the importance of sourcing it from reputable chemical suppliers is vital for any pharmaceutical manufacturer.

Understanding 2-((6-Chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile (CAS 865758-95-8)

This compound, appearing as a light yellow solid, is characterized by its molecular formula C12H8ClN3O2 and a molecular weight of approximately 261.664. Its purity, typically specified at ≥98%, along with controlled moisture content (≤1%) and impurity levels (≤0.5%), directly influences the quality and yield of the final Alogliptin API. The synthesis of Alogliptin involves intricate steps where this intermediate acts as a foundational building block. Therefore, securing a consistent supply of high-quality Alogliptin intermediate from a reliable manufacturer in China is a strategic necessity for pharmaceutical companies.

The Critical Role in Alogliptin Synthesis

Alogliptin functions as a DPP-4 inhibitor, enhancing the body's response to insulin and thereby controlling blood glucose levels in type 2 diabetes. The synthetic route to Alogliptin utilizes 2-((6-Chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile to introduce specific molecular structures required for its pharmacological activity. The efficiency and success of these synthesis steps are directly dependent on the purity and reactivity of the starting intermediate. Pharmaceutical research and development teams often seek to buy CAS 865758-95-8 from suppliers who can guarantee batch-to-batch consistency, ensuring reproducible results in their manufacturing processes.

Sourcing Strategies for Pharmaceutical Manufacturers

For companies looking to order 2-((6-Chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile, partnering with experienced chemical manufacturers in China offers significant advantages. These include competitive pricing, access to large-scale production capabilities, and a well-established logistical network. It is crucial to vet potential suppliers thoroughly, verifying their quality control measures, production capacity, and ability to provide comprehensive documentation, such as Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS). NINGBO INNO PHARMCHEM CO.,LTD. is a prominent supplier of pharmaceutical intermediates, dedicated to providing high-quality products that meet the demanding specifications of the global pharmaceutical industry. We are equipped to fulfill orders for high-purity Alogliptin intermediates, ensuring your synthesis projects proceed smoothly and efficiently.

In conclusion, the intermediate 2-((6-Chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile is indispensable for Alogliptin production. By prioritizing quality and reliability when choosing a supplier, pharmaceutical manufacturers can secure the essential components needed for life-saving medications.