For professionals in the pharmaceutical industry, securing high-quality intermediates is paramount for the successful development and manufacturing of life-saving drugs. One such crucial compound is (1S,4R)-4-Amino-2-cyclopentene-1-methanol D-hydrogen tatrate (CAS 229177-52-0). This article aims to provide valuable insights for procurement managers and R&D scientists seeking this specific pharmaceutical intermediate, highlighting its importance and considerations when you choose to buy.

Understanding the Significance of the Intermediate

(1S,4R)-4-Amino-2-cyclopentene-1-methanol D-hydrogen tatrate serves as a key intermediate in the synthesis of Abacavir. Abacavir is a highly effective nucleoside analog reverse transcriptase inhibitor (NRTI) used in the treatment of HIV-1 infection. The specific stereochemistry of the intermediate, denoted as (1S,4R)-cis, is critical for the final drug's efficacy and its ability to interact with the target viral enzyme. When procuring this chemical, ensuring the correct enantiomeric purity is a non-negotiable aspect for API manufacturers.

Key Considerations for Sourcing and Purchase

When you decide to buy (1S,4R)-4-Amino-2-cyclopentene-1-methanol D-hydrogen tatrate, several factors are crucial:

  • Purity and Quality: The compound is typically a white solid and requires a high assay, often 99.0% or more, for pharmaceutical applications. Working with a reputable manufacturer that provides a Certificate of Analysis (CoA) detailing purity and impurity profiles is essential. This ensures that your downstream synthesis processes are not compromised.
  • Supplier Reliability: Identifying a dependable manufacturer and supplier is key to maintaining an uninterrupted production line. Consider suppliers who can offer consistent quality, competitive pricing, and flexible shipping options. For many global buyers, seeking a manufacturer in China can offer significant cost advantages without sacrificing quality, provided stringent quality controls are in place.
  • Chemical Properties: While primarily used as an intermediate, understanding its basic chemical properties, such as solubility (slightly soluble in DMSO and methanol) and melting point (decomposes above 120°C), can be beneficial for handling and initial formulation research.
  • Regulatory Compliance: For pharmaceutical use, intermediates must be manufactured under conditions that align with industry standards, even if not requiring full GMP certification at the intermediate stage. Familiarizing yourself with the supplier's manufacturing practices is advisable.

Why Choose a Chinese Manufacturer?

China has emerged as a global powerhouse for chemical manufacturing, offering a vast network of producers for pharmaceutical intermediates. By partnering with a specialized Chinese manufacturer like NINGBO INNO PHARMCHEM CO.,LTD., you can access:

  • Cost-Effectiveness: Benefit from competitive pricing structures that can significantly reduce your raw material costs. Obtaining a quote from a direct manufacturer eliminates intermediary markups.
  • Scale and Capacity: Reputable Chinese manufacturers often possess the capacity to handle large-volume orders, ensuring your supply needs are met as your production scales up.
  • Specialized Expertise: Many Chinese chemical companies have honed their expertise in synthesizing complex molecules, including chiral intermediates crucial for pharmaceuticals.

In conclusion, sourcing (1S,4R)-4-Amino-2-cyclopentene-1-methanol D-hydrogen tatrate requires careful consideration of purity, supplier reliability, and cost-effectiveness. By engaging with established manufacturers in China, you can ensure a stable supply of this vital antiviral intermediate, supporting the critical work of combating global health challenges. If you are looking to buy this product, reaching out to NINGBO INNO PHARMCHEM CO.,LTD. for a quote and sample is a strategic first step in securing a high-quality, cost-efficient supply chain.