For procurement managers and R&D scientists in the pharmaceutical sector, sourcing critical intermediates like N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-2-propenamide (CAS 130929-57-6) is a meticulous process. This compound, vital for synthesizing drugs that target conditions like Parkinson's disease, demands a supplier who can guarantee purity, consistency, and a stable supply chain. This guide aims to equip you with the knowledge to make informed purchasing decisions and identify a reliable manufacturer.

Understanding the Need for High-Purity Intermediates

N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-2-propenamide, identified by CAS 130929-57-6, plays a crucial role as a catechol-O-methyltransferase (COMT) inhibitor. Its primary application lies in enhancing the efficacy of levodopa therapy for Parkinson's disease. The efficacy and safety of the final drug product are directly dependent on the quality of this intermediate. Therefore, procurement professionals must prioritize suppliers who demonstrate rigorous quality control measures and provide detailed Certificates of Analysis (CoA).

Key Considerations When Buying CAS 130929-57-6

When seeking to buy this pharmaceutical intermediate, several factors are paramount:

  • Purity Levels: For pharmaceutical applications, high purity (typically >98%) is non-negotiable. Inquire about analytical methods used (e.g., HPLC, NMR) to verify purity.
  • Manufacturing Standards: Does the manufacturer adhere to Good Manufacturing Practices (GMP) or equivalent quality systems? This is critical for regulated markets.
  • Supply Chain Reliability: A consistent supply is essential. Investigate the supplier's production capacity, lead times, and their ability to manage potential disruptions. Purchasing from a China-based manufacturer can offer cost advantages, but logistical planning is key.
  • Technical Support: A knowledgeable supplier can provide valuable insights into the compound's properties, handling, and potential applications, aiding your research and development efforts.
  • Pricing and Quotations: Obtaining competitive price quotes is crucial for cost-effective drug development. Engage with manufacturers directly to understand bulk pricing structures.

Finding a Reliable Manufacturer in China

China has emerged as a significant hub for chemical manufacturing, including high-quality pharmaceutical intermediates. When selecting a supplier, look for established companies with a proven track record in exporting. Companies that clearly state their capabilities, production capacity, and commitment to quality are typically preferred. For instance, understanding the manufacturing process and the raw materials used can provide further confidence in the product's integrity.

Conclusion

Securing a consistent and high-quality supply of N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-2-propenamide (CAS 130929-57-6) is a strategic imperative for pharmaceutical companies. By focusing on purity, supplier reliability, and obtaining comprehensive technical data, procurement specialists can ensure the success of their drug development projects. We encourage you to contact us for detailed product specifications, quotations, and to discuss your bulk purchase requirements for this vital pharmaceutical intermediate.