For pharmaceutical manufacturers focused on developing dermatological treatments, sourcing high-quality intermediates is paramount. One such critical component is 2-Bromo-5-hydroxybenzaldehyde (CAS 2973-80-0), a vital building block in the synthesis of Crisaborole. Understanding the nuances of procuring this compound can significantly impact the efficiency and success of your API production. This guide aims to provide procurement managers and R&D scientists with the essential information needed to make informed purchasing decisions from reliable suppliers.

Understanding 2-Bromo-5-hydroxybenzaldehyde:

2-Bromo-5-hydroxybenzaldehyde, with the CAS number 2973-80-0, is a chemical intermediate characterized by its specific molecular structure and reactivity. Its primary role in the pharmaceutical industry is as a precursor in the multi-step synthesis of Crisaborole, a non-steroidal topical anti-inflammatory drug used for the treatment of mild to moderate atopic dermatitis. The purity and consistency of this intermediate directly influence the quality and efficacy of the final active pharmaceutical ingredient (API).

Key Considerations When Sourcing:

When looking to buy 2-Bromo-5-hydroxybenzaldehyde, several factors are crucial:

  • Purity Levels: For pharmaceutical applications, a high purity level, typically above 98%, is non-negotiable. Impurities can lead to side reactions, reduced yields, and potential regulatory hurdles. Always request detailed Certificates of Analysis (CoA) that specify purity and identify any residual impurities.
  • Supplier Reliability: Partnering with a reputable manufacturer and supplier is essential. Look for companies with established quality management systems (like ISO 9001 or GMP certifications where applicable) and a proven track record in supplying pharmaceutical intermediates. Suppliers in China are often competitive in terms of price and volume.
  • Documentation and Regulatory Support: A dependable supplier will provide comprehensive documentation, including CoAs, MSDS sheets, and potentially support for regulatory filings. Understanding the origin and manufacturing process is also vital.
  • Pricing and Bulk Orders: While quality is paramount, competitive pricing is also a consideration for large-scale manufacturing. Inquire about bulk purchase discounts and contract manufacturing options to secure a stable supply at an optimal price.

Navigating the Supply Chain:

The global market offers numerous suppliers for 2-Bromo-5-hydroxybenzaldehyde. Identifying the right manufacturer requires diligence. Companies specializing in pharmaceutical intermediates and custom synthesis are often best equipped to meet the demanding standards of the industry. When searching for a supplier, use terms like 'buy 2-bromo-5-hydroxybenzaldehyde supplier,' '2-bromo-5-hydroxybenzaldehyde price China,' or 'crisaborole intermediate manufacturer' to find relevant sources. Direct inquiries to suppliers can help clarify lead times, minimum order quantities (MOQs), and shipping capabilities.

Choosing NINGBO INNO PHARMCHEM CO.,LTD. as Your Supplier:

As a trusted provider of pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. is committed to delivering high-purity 2-Bromo-5-hydroxybenzaldehyde to support your Crisaborole manufacturing needs. We offer a reliable supply chain, rigorous quality control, and excellent customer service. Our expertise in chemical synthesis and commitment to customer satisfaction make us an ideal partner for your procurement requirements. Contact us today to discuss your needs and obtain a competitive quote.