For procurement managers and R&D scientists in the pharmaceutical sector, sourcing critical intermediates like Ethyl 4,4,4-Trifluorobut-2-ynoate (CAS: 79424-03-6) is paramount to project success. This fluorinated building block, with its unique chemical structure, plays a vital role in the synthesis of various advanced organic compounds, particularly those with enhanced pharmacological properties. As a leading manufacturer and supplier based in China, NINGBO INNO PHARMCHEM CO.,LTD. understands the demands for high purity (typically 99% min), consistent quality, and reliable delivery. This article aims to guide you through the process of identifying and purchasing this essential chemical.

Understanding Ethyl 4,4,4-Trifluorobut-2-ynoate's Value

Ethyl 4,4,4-Trifluorobut-2-ynoate, also known by synonyms such as ethyl trifluoromethylpropiolate, is characterized by its trifluoromethyl group and alkyne functionality. These features make it an excellent precursor for introducing fluorine atoms and creating complex carbon frameworks. Its molecular formula is C6H5F3O2, with a molecular weight of approximately 166.098 g/mol. Its boiling point of around 96-98°C and density of 1.162 g/mL at 25°C are important parameters for handling and reaction design.

A significant application of this compound is in the synthesis of 2-fluoroalkylated 1,3-benzodioxole derivatives. This is often achieved through a double Michael-addition reaction with corresponding catechols. Such reactions are fundamental in developing novel therapeutic agents, where the precise incorporation of fluorine can significantly influence drug efficacy, metabolic stability, and lipophilicity. For any R&D scientist looking to buy this intermediate, understanding its reactivity is key to successful synthesis.

Key Considerations When Purchasing

When you are ready to buy Ethyl 4,4,4-Trifluorobut-2-ynoate, several factors should guide your decision. As a procurement specialist, you'll be looking for a reputable manufacturer that can guarantee a stable supply chain and consistent product quality. Specifically, seeking a supplier in China often provides access to competitive pricing and robust manufacturing capabilities.

Key specifications to confirm with any potential supplier include:

  • Purity: Aim for a minimum purity of 99% for sensitive pharmaceutical applications.
  • CAS Number: Ensure the CAS number is correctly identified as 79424-03-6.
  • Packaging: Availability in various sizes (e.g., 25g, 100g, 500g, bulk) to suit different project scales.
  • Documentation: Access to Certificates of Analysis (CoA) and other relevant technical data.
  • Lead Times: Realistic delivery estimates for both small and large orders.

Why Choose NINGBO INNO PHARMCHEM CO.,LTD.?

At NINGBO INNO PHARMCHEM CO.,LTD., we are dedicated to meeting the needs of the global pharmaceutical and chemical industries. We pride ourselves on being a reliable manufacturer and supplier of high-quality pharmaceutical intermediates. Our commitment to excellence ensures that when you purchase Ethyl 4,4,4-Trifluorobut-2-ynoate from us, you receive a product that adheres to the highest standards, backed by exceptional customer service. We actively work with clients to understand their specific requirements and offer tailored solutions, whether for laboratory-scale research or large-scale industrial production. Get in touch with us today to request a quote or sample and experience the difference of partnering with a trusted chemical expert.