For procurement managers and R&D scientists in the pharmaceutical and fine chemical industries, sourcing high-quality intermediates is paramount. One such critical compound is 2-Amino-4-thiazoleacetic acid (CAS 29676-71-9). This article serves as a comprehensive guide for buyers looking to purchase this essential building block, focusing on specifications, applications, and identifying reliable manufacturers and suppliers. Understanding the nuances of this chemical can significantly impact the efficiency and success of your synthesis projects.

Understanding 2-Amino-4-thiazoleacetic Acid

2-Amino-4-thiazoleacetic acid is a white to yellowish or brown crystalline powder, characterized by its unique chemical structure and properties. Its molecular formula is C5H6N2O2S, with a molecular weight of 158.18. The compound is notable for its role as a key intermediate in the synthesis of various pharmaceutical compounds, most prominently cefotiam, a widely used cephalosporin antibiotic. For those looking to buy 2-amino-4-thiazoleacetic acid, understanding its purity and physical characteristics is the first step.

Key Specifications for Procurement

When evaluating suppliers, procurement professionals should pay close attention to several key specifications. The purity of 2-amino-4-thiazoleacetic acid is a critical factor; a minimum purity of ≥98.0% is typically required for pharmaceutical synthesis to ensure the efficacy and safety of the final drug product. Other important parameters include its melting point, which is around 130°C (with decomposition), and its solubility characteristics. Reliable manufacturers will provide detailed Certificates of Analysis (CoA) for each batch, confirming these specifications. When searching for a 2-amino-4-thiazoleacetic acid supplier, prioritize those who offer transparency in their product data.

Primary Applications in Pharmaceutical Synthesis

The primary application of 2-Amino-4-thiazoleacetic acid lies in its role as a crucial intermediate for the synthesis of Active Pharmaceutical Ingredients (APIs). Specifically, it is indispensable in the production of cefotiam. This means that the availability and quality of this intermediate directly influence the production capacity and cost-effectiveness of cefotiam manufacturing. Researchers also utilize it as a versatile building block in various organic synthesis pathways, exploring new thiazole-based compounds with potential therapeutic applications.

Finding Reliable Manufacturers and Suppliers in China

China is a major hub for chemical manufacturing, and sourcing 2-amino-4-thiazoleacetic acid from reputable Chinese manufacturers can offer significant cost advantages. When looking to purchase 2-amino-4-thiazoleacetic acid, it is essential to vet potential suppliers thoroughly. Look for companies with established quality control systems, a proven track record in exporting pharmaceutical intermediates, and certifications that demonstrate adherence to international standards. Engaging with a direct manufacturer of 2-amino-4-thiazoleacetic acid often leads to better pricing and more direct communication regarding product specifications and delivery timelines.

Navigating the Purchase Process

For businesses in need of this chemical, initiating a quote request is the typical next step. When contacting potential suppliers, clearly state your requirements, including the quantity needed, desired purity, and any specific packaging requirements. Inquire about lead times and payment terms. Understanding the total cost, including shipping and any import duties, is crucial for making an informed purchasing decision. Consider the logistical aspects as well – many suppliers offer packaging in 25 kg drums or can accommodate customer-specific packaging needs. By diligently researching and comparing options, you can secure a consistent and high-quality supply of 2-amino-4-thiazoleacetic acid.

In conclusion, securing a reliable source for 2-Amino-4-thiazoleacetic acid is vital for pharmaceutical companies. By focusing on purity, understanding its applications, and partnering with reputable manufacturers and suppliers, you can ensure the smooth progression of your drug synthesis and development projects. For competitive pricing and quality assurance, consider sourcing your 2-amino-4-thiazoleacetic acid from trusted Chinese manufacturers.