For procurement managers and R&D scientists in the pharmaceutical and agrochemical sectors, sourcing high-quality intermediates is paramount. 2-Hydroxy-3-trifluoromethylpyridine (CAS 22245-83-6) stands out as a critical building block, prized for its unique fluorinated pyridine structure. This article aims to guide you through understanding its properties and effectively sourcing this essential chemical.

Understanding 2-Hydroxy-3-trifluoromethylpyridine

This compound, also known by synonyms such as 3-(Trifluoromethyl)pyridin-2-ol or 3-(Trifluoromethyl)-2-pyridone, features a pyridine ring with a hydroxyl group and a trifluoromethyl (-CF3) substituent. The CF3 group significantly influences its lipophilicity and metabolic stability, making it highly valuable in medicinal chemistry and the development of new agrochemicals. Its typical appearance is an off-white crystalline powder, with a melting point usually in the range of 150-153°C. This chemical is a key intermediate for organic synthesis, enabling the creation of more complex molecules with desirable biological activities.

Key Applications in Synthesis

The utility of 2-Hydroxy-3-trifluoromethylpyridine spans several critical areas:

  • Pharmaceutical Intermediates: It serves as a precursor for synthesizing Active Pharmaceutical Ingredients (APIs). The incorporation of the trifluoromethyl group can often enhance a drug candidate's potency, bioavailability, and resistance to metabolic degradation. Researchers actively seek this compound for developing novel therapeutics.
  • Agrochemicals: In the agrochemical industry, this intermediate contributes to the development of advanced crop protection agents. Its structural features can impart stability against environmental factors, leading to more effective and longer-lasting pest or weed control solutions.
  • General Organic Synthesis: Beyond these primary applications, it's a versatile reactant in broader organic synthesis, allowing chemists to build intricate molecular architectures for various research and industrial purposes.

Sourcing Strategies: Finding Reliable Suppliers and Manufacturers

When you need to buy 2-Hydroxy-3-trifluoromethylpyridine, focusing on purity and reliability is key. As a chemical procurement specialist, you’ll want to partner with a reputable manufacturer and supplier, especially those based in China, which is a global hub for fine chemical production. Key considerations when evaluating a supplier include:

  • Purity Levels: Look for specifications stating u226598.0% assay purity, ensuring the quality needed for sensitive synthesis reactions.
  • Production Capacity: Can the manufacturer support your scale requirements, from R&D quantities to bulk orders?
  • Technical Support and Documentation: Access to Material Safety Data Sheets (MSDS) and technical specifications is crucial for safe handling and process integration.
  • Pricing and Lead Times: Obtaining competitive quotes and understanding delivery timelines are vital for project planning.

For those seeking a dependable 2-Hydroxy-3-trifluoromethylpyridine supplier, exploring options from established chemical manufacturers in China can yield excellent results. These suppliers often provide competitive pricing and a consistent supply chain, making it easier to secure the materials needed for your ongoing projects.

Conclusion

2-Hydroxy-3-trifluoromethylpyridine is an indispensable intermediate for chemists engaged in pharmaceutical and agrochemical innovation. By understanding its properties and implementing a robust sourcing strategy, you can ensure the quality and availability of this critical compound. Whether you are looking to buy 3-(Trifluoromethyl)pyridin-2-ol for the first time or scale up existing processes, partnering with a trusted manufacturer and supplier is your pathway to success.