For procurement managers in the chemical and pharmaceutical industries, sourcing reliable, high-purity intermediates is paramount. 2-Hydroxy-5-methylpyridine (CAS 1003-68-5) stands out as a critical building block, particularly in pharmaceutical synthesis. Understanding its properties, applications, and the best channels to buy this compound is key to optimizing your supply chain.

What is 2-Hydroxy-5-methylpyridine?

Also known by synonyms such as 5-methyl-2-pyridinol or 2-hydroxy-5-picoline, this heterocyclic compound (C6H7NO) is a valuable intermediate. Its molecular structure features a pyridine ring with a hydroxyl group and a methyl substituent, lending it specific reactivity essential for various chemical transformations. The compound is typically supplied as a white solid, with a purity often exceeding 95% by HPLC, making it suitable for demanding applications.

Key Applications in the Industry

The primary utility of 2-Hydroxy-5-methylpyridine lies in its role as an intermediate in the synthesis of more complex molecules. Its significance is particularly pronounced in:

  • Pharmaceutical Development: It is a crucial intermediate in the synthesis of Active Pharmaceutical Ingredients (APIs). Notably, it is recognized as Pirfenidone Impurity B, making its controlled use and purity essential in the manufacturing of antifibrotic drugs like Pirfenidone, used for Idiopathic Pulmonary Fibrosis (IPF). Researchers often seek to buy this compound for drug discovery and development processes.
  • Agrochemicals: The compound also finds application in the agrochemical sector, serving as a building block for herbicides and fungicides. Its incorporation can enhance the efficacy and stability of crop protection agents.
  • Organic Synthesis: In broader organic synthesis, it acts as a versatile synthon, enabling the creation of various heterocyclic structures and functionalized compounds.
  • Analytical Chemistry: It can be employed as a reagent in analytical techniques, aiding in the identification and quantification of other substances.

Sourcing and Purchasing Considerations

When looking to purchase 2-Hydroxy-5-methylpyridine, procurement managers should prioritize suppliers that offer:

  • High Purity and Consistent Quality: Ensure the supplier can provide a Certificate of Analysis (CoA) detailing purity, typically via HPLC or GC.
  • Competitive Pricing: Especially for bulk orders, securing a favorable price from a direct manufacturer is essential for cost-effectiveness. Manufacturers in China are often a primary source for competitive pricing.
  • Reliable Supply and Logistics: A stable supply chain and efficient delivery are critical to avoid production delays. Look for suppliers with a proven track record in global distribution.
  • Regulatory Compliance: For pharmaceutical applications, ensure the supplier adheres to relevant quality standards and can provide necessary documentation.

Finding a Manufacturer and Supplier in China

China hosts a significant number of chemical manufacturers and suppliers for intermediates like 2-Hydroxy-5-methylpyridine. When selecting a supplier, consider their product range, manufacturing capacity, quality certifications, and customer support. Engaging with manufacturers directly can often lead to better pricing and more tailored solutions for bulk purchases. For example, companies specializing in fine chemical intermediates and pharmaceutical materials are prime candidates. Conducting thorough due diligence, including requesting samples and reviewing supplier credentials, is a prudent step before committing to a purchase.

In conclusion, 2-Hydroxy-5-methylpyridine is an indispensable intermediate for many chemical processes. By understanding its applications and focusing on reliable manufacturers and suppliers in China, procurement professionals can ensure a consistent and high-quality supply, crucial for the success of their projects. For those seeking to buy this essential compound, partnering with a reputable manufacturer ensures both quality and competitive pricing.