2-Hydroxy-5-methylpyridine (CAS 1003-68-5) is a fundamental building block in organic chemistry, valued for its distinct properties and synthetic versatility. As a leading supplier of fine chemical intermediates, we aim to provide a comprehensive understanding of this compound, from its synthesis to its characteristic attributes, enabling researchers and manufacturers to make informed purchasing decisions.

Chemical Identity and Properties

2-Hydroxy-5-methylpyridine, also known as 5-methyl-2-pyridinol, is a heterocyclic organic compound with the molecular formula C6H7NO and a molecular weight of 109.13 g/mol. It typically presents as a white to pale yellow crystalline solid. Its melting point is generally reported in the range of 181-187 °C, indicating its solid state at room temperature. The compound exhibits solubility in polar organic solvents such as ethanol, methanol, and DMSO, which is a common characteristic for molecules with hydroxyl functionalities.

Key Synthesis Routes

While specific proprietary synthesis routes exist, common methods for preparing 2-Hydroxy-5-methylpyridine often involve transformations of related pyridine derivatives. One general approach described in literature involves cyclization and functionalization steps, potentially starting from simpler precursors. For instance, processes might involve the cyclization of an appropriate open-chain compound followed by hydroxylation or the modification of existing substituted pyridines. Researchers and manufacturers often look to buy high-purity material that has undergone efficient synthesis to minimize impurities and maximize yield in subsequent reactions.

Reactivity and Applications in Synthesis

The chemical reactivity of 2-Hydroxy-5-methylpyridine stems from its functional groups:

  • Hydroxyl Group: The -OH group can participate in esterification, etherification, and other reactions characteristic of alcohols and phenols. It also contributes to tautomerism, existing in equilibrium with its pyridone form (5-methylpyridin-2(1H)-one).
  • Pyridine Ring: The aromatic nitrogen in the pyridine ring can act as a nucleophile or a base, and the ring itself can undergo electrophilic or nucleophilic aromatic substitution reactions, depending on the conditions and activating/deactivating substituents.
  • Methyl Group: The methyl group can be activated for various reactions, such as oxidation or condensation, under specific conditions.

These reactive sites make 2-Hydroxy-5-methylpyridine a valuable intermediate for synthesizing complex molecules, including pharmaceuticals like Pirfenidone and various agrochemicals. Its ability to undergo a range of transformations allows chemists to build diverse molecular architectures.

Quality and Sourcing for Industrial Use

For industrial applications, sourcing 2-Hydroxy-5-methylpyridine from reliable manufacturers is paramount. Key considerations include:

  • Purity: Ensuring high purity (e.g., >95% HPLC) is crucial for consistent reaction outcomes and product quality.
  • Scalability: Manufacturers must have the capacity to produce the compound in quantities required for commercial use.
  • Cost-Effectiveness: Competitive pricing, especially for bulk purchases, is vital for economic viability. China-based manufacturers often offer attractive price points.
  • Technical Data: Availability of comprehensive technical data sheets (TDS), safety data sheets (SDS), and Certificates of Analysis (CoAs) is essential for quality assurance and safety handling.

By understanding the synthesis pathways and inherent properties of 2-Hydroxy-5-methylpyridine, customers can better select suppliers and utilize this versatile intermediate effectively in their research and manufacturing processes. When you choose to buy this compound, partnering with experienced chemical suppliers ensures you receive material that meets your exacting standards.