For pharmaceutical researchers and procurement managers, securing reliable sources of key intermediates is paramount. One such critical compound is 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (CAS: 90213-66-4). This heterocycle plays a pivotal role in the synthesis of important active pharmaceutical ingredients (APIs), most notably Tofacitinib citrate. Understanding its properties and where to buy it is essential for efficient drug development.

Understanding the Importance of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, with its molecular formula C6H3Cl2N3 and a molecular weight of approximately 188.01 g/mol, is characterized by its white powder appearance and a melting point typically in the range of 247-250°C. Its significance stems from its structure, which is a precursor to the pyrrolo[2,3-d]pyrimidine core found in many therapeutic agents. Specifically, it's a key building block in the multi-step synthesis of Tofacitinib, a widely prescribed medication for rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. The purity of this intermediate, often specified at ≥99%, directly impacts the yield and purity of the final API, making quality control a non-negotiable aspect of its procurement.

Where to Buy and Key Sourcing Considerations

When looking to purchase 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, procurement managers should focus on reliable manufacturers and suppliers, particularly those based in China, which is a major hub for fine chemical production. Key considerations include:

  • Purity Levels: Always verify that the supplier can consistently provide material meeting the required purity specifications (e.g., ≥99% by HPLC).
  • Supplier Reputation: Choose established suppliers with a proven track record in the pharmaceutical intermediate market. Look for certifications or audit reports if available.
  • Pricing and MOQ: Obtain quotes from multiple manufacturers to ensure competitive pricing. Understand the Minimum Order Quantity (MOQ) for bulk purchases.
  • Technical Data: Request comprehensive technical data sheets (TDS), Certificates of Analysis (CoA), and Material Safety Data Sheets (MSDS) to confirm product quality and handling requirements.
  • Supply Chain Stability: Partnering with a manufacturer that demonstrates robust production capacity and a stable supply chain is crucial for uninterrupted production.

For businesses seeking to purchase 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, engaging with experienced chemical suppliers who specialize in pharmaceutical intermediates is highly recommended. Such suppliers can offer not only the product itself but also technical support and efficient logistics. For those requiring Tofacitinib synthesis intermediates, identifying a trusted manufacturer in China ensures access to this vital compound at a competitive price, facilitating smoother R&D and production cycles.