In the competitive landscape of pharmaceutical development, securing a consistent supply of high-quality raw materials and intermediates is paramount. For those engaged in synthesizing complex APIs, understanding the procurement process for compounds like 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (CAS: 90213-66-4) is essential. This article aims to guide procurement managers and researchers on how to effectively source this key intermediate, focusing on quality, supplier selection, and pricing.

Understanding the Product: 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

This white crystalline powder is characterized by its molecular formula C6H3Cl2N3 and a molecular weight of 188.01. It is widely recognized as a crucial intermediate in the synthesis of Tofacitinib citrate, a significant pharmaceutical compound. The compound's structure features reactive chlorine atoms that allow for further functionalization, making it a valuable building block in organic synthesis. When you intend to buy this chemical, expect specifications to include a purity of ≥99% and a well-defined melting point (247-250°C).

Identifying Reliable Suppliers and Manufacturers

When it comes to purchasing 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, especially in bulk quantities, partnering with reliable suppliers is key. Key criteria for selecting a supplier include:

  • Quality Assurance: Prioritize suppliers who provide comprehensive Certificates of Analysis (CoA) detailing purity, impurity profiles, and physical properties. A minimum purity of 99% is generally expected for pharmaceutical applications.
  • Manufacturer vs. Distributor: Direct manufacturers often offer better pricing and greater control over the production process. However, reputable distributors can also provide excellent service and readily available stock.
  • Geographic Location: Manufacturers in China are a primary source for many fine chemical intermediates, often providing competitive pricing and substantial production capacity.
  • Customer Support and Logistics: Ensure the supplier has responsive customer service and efficient shipping capabilities to meet your project timelines.
  • Technical Documentation: Access to Material Safety Data Sheets (MSDS), technical data sheets (TDS), and NMR/IR spectra can be crucial for validating the product.

Navigating Pricing and Volume Purchases

The price of 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine is influenced by factors such as purity, order volume, and market demand. When seeking to buy, it is advisable to obtain multiple quotes from different suppliers. For significant R&D projects or commercial production, establishing a relationship with a consistent manufacturer can lead to better pricing tiers and a more stable supply chain. Understanding these aspects will empower you to make informed purchasing decisions and secure this essential pharmaceutical intermediate effectively.