For procurement managers and R&D scientists in the pharmaceutical industry, sourcing high-quality raw materials is paramount. One such critical component is 4-Hydroxy-D-phenylglycine, identified by CAS number 22818-40-2. This chiral amino acid derivative is a cornerstone in the synthesis of essential semi-synthetic antibiotics, making its reliable supply a key concern for manufacturers. This article aims to guide you through understanding and acquiring this vital pharmaceutical intermediate.

Why is 4-Hydroxy-D-phenylglycine Crucial?

4-Hydroxy-D-phenylglycine (often abbreviated as D-PHPG) is primarily utilized as a side chain in the production of widely prescribed antibiotics such as amoxicillin and cefadroxil. Its specific stereochemistry is critical for the pharmacological activity of these beta-lactam antibiotics. Without a consistent and high-purity supply of this intermediate, the efficient and effective manufacturing of these life-saving drugs would be significantly hampered. Therefore, understanding its applications and specifications is essential for anyone involved in antibiotic production.

Key Specifications and Quality Parameters

When you purchase 4-Hydroxy-D-phenylglycine, looking for specific quality indicators is crucial. Typically, this compound is supplied as a white or almost white crystalline powder. A minimum assay of 99% is generally expected, along with controlled levels of moisture and other impurities. The specific rotation also plays a role in confirming its chiral identity and purity. As a reputable chemical manufacturer and supplier, ensuring these specifications are met is our top priority. We understand that consistent quality directly impacts the final drug product's efficacy and regulatory compliance. For those looking to buy 4-Hydroxy-D-phenylglycine, always verify the Certificate of Analysis (CoA) provided by the supplier.

Finding Reliable Suppliers and Manufacturers in China

China has emerged as a global hub for pharmaceutical intermediates, and finding a reliable manufacturer for 4-Hydroxy-D-phenylglycine is achievable. When searching for a supplier, consider factors such as:

  • Manufacturing Capabilities: Does the manufacturer have robust synthesis processes and quality control measures in place?
  • Purity and Certifications: Do they consistently meet or exceed the required purity levels and possess relevant certifications?
  • Supply Chain Stability: Can they guarantee a steady and timely supply to meet your production schedules?
  • Customer Service and Technical Support: Are they responsive to inquiries and capable of providing technical assistance?

Engaging with established chemical suppliers who specialize in pharmaceutical intermediates can streamline your procurement process. For those seeking to purchase 4-Hydroxy-D-phenylglycine, inquiring about bulk orders and pricing is a standard step. A good supplier will be transparent about their manufacturing practices and ready to provide samples for your evaluation.

Cost and Procurement Considerations

The price of 4-Hydroxy-D-phenylglycine can vary based on purity, order volume, and market dynamics. However, by sourcing directly from manufacturers in China, businesses can often achieve significant cost efficiencies. It's advisable to solicit quotes from multiple reputable suppliers to compare pricing and terms. When you request a quote for 4-Hydroxy-D-phenylglycine, be sure to specify the required quantity and any particular quality specifications you may have. This will help suppliers provide an accurate and competitive price for their product.

In conclusion, securing a dependable source of 4-Hydroxy-D-phenylglycine is critical for pharmaceutical companies manufacturing antibiotics. By understanding the product's importance, specifications, and by diligently selecting a trusted manufacturer and supplier, you can ensure the continuity and quality of your production lines. For those in need, exploring partnerships with experienced chemical companies that offer this key intermediate is a strategic step towards successful drug manufacturing.