For professionals in the chemical and pharmaceutical sectors, a deep understanding of compound properties is crucial for successful procurement and application. This article focuses on 4-Hydroxy-D-phenylglycine, identified by CAS number 22818-40-2, a compound widely used as a pharmaceutical intermediate. We will explore its chemical profile, specifications, and the advantages of sourcing it from a reliable manufacturer and supplier.

Chemical Identity and Physical Properties

4-Hydroxy-D-phenylglycine is a chiral amino acid derivative with the molecular formula C8H9NO3. Its structure features a phenyl ring substituted with a hydroxyl group, attached to an alpha-amino acetic acid moiety in the D-configuration. Physically, it is typically presented as a white to off-white crystalline powder. Its solubility characteristics are notable: it is slightly soluble in ethanol and water but readily dissolves in acidic or alkaline solutions, forming salts. This solubility profile is important for formulation and reaction conditions in pharmaceutical synthesis.

Key Specifications for Pharmaceutical Use

When procuring 4-Hydroxy-D-phenylglycine for pharmaceutical applications, adhering to strict specifications is non-negotiable. Key parameters include:

  • Assay: Typically, a purity of ≥99.00% is required to ensure the efficacy and safety of derived active pharmaceutical ingredients (APIs).
  • Appearance: White or almost white crystalline powder.
  • Moisture Content: Usually specified as ≤0.20% to maintain product stability.
  • Specific Rotation: A defined range, such as -156.0° to -161.0°, confirms its chiral purity.
  • Iron Content: Low levels, typically ≤5mg/kg, are important for pharmaceutical purity standards.

As a leading chemical manufacturer and supplier, we prioritize meeting these rigorous specifications. Our commitment to quality ensures that every batch of 4-Hydroxy-D-phenylglycine delivered upholds the highest industry standards. For R&D scientists and procurement managers looking to buy this intermediate, understanding these specifications is key to selecting the right product.

Applications and Market Significance

The primary application of 4-Hydroxy-D-phenylglycine is its indispensable role as an intermediate in the synthesis of critical semi-synthetic antibiotics, most notably amoxicillin and cefadroxil. Its unique structure contributes to the pharmacological activity of these beta-lactam antibiotics. Beyond its direct use in drug synthesis, it also finds application as an impurity reference standard in quality control processes, aiding pharmaceutical companies in maintaining product integrity.

For businesses seeking to purchase 4-Hydroxy-D-phenylglycine, engaging with a reputable supplier in China offers distinct advantages, including competitive pricing and a stable supply chain. We provide comprehensive support, including technical data sheets and readily available quotes for bulk orders. Whether you are developing new formulations or scaling up existing production, our team is ready to assist you in sourcing this vital pharmaceutical intermediate.