For any organization involved in chemical synthesis, particularly in the pharmaceutical and biotechnology sectors, the procurement of specialized reagents like Boc-L-4-Bromophenylalanine (CAS 62129-39-9) demands careful consideration. As a key building block for peptide synthesis and a valuable pharmaceutical intermediate, its quality and availability directly impact research outcomes and production timelines. This guide aims to assist procurement managers and R&D scientists in making informed purchasing decisions.

Understanding the product is the first step. Boc-L-4-Bromophenylalanine is an N-protected amino acid derivative with a molecular formula of C14H18BrNO4 and a molecular weight of approximately 344.2 g/mol. It typically presents as an off-white to white powder. The crucial features are the Boc protecting group on the alpha-amino nitrogen and the bromine atom at the para position of the phenyl ring. These structural elements are critical for its function in solid-phase peptide synthesis (SPPS), where the Boc group ensures controlled coupling, and the bromine atom allows for further chemical elaboration. Its optical purity is also a significant factor, and suppliers typically specify enantiomeric excess (e.e.) values.

When you intend to buy Boc-L-4-Bromophenylalanine, purity is a paramount concern. Reputable suppliers, especially manufacturers, will guarantee a high level of purity, commonly stated as ≥98% by HPLC. This ensures that the reagent is free from significant impurities that could interfere with sensitive synthetic reactions or lead to unwanted byproducts. Always request a Certificate of Analysis (CoA) for each batch to confirm the specifications, including purity, optical rotation, and other relevant physical properties.

The role of Boc-L-4-Bromophenylalanine as a pharmaceutical intermediate cannot be overstated. It serves as a versatile scaffold for constructing complex molecules, enabling the development of novel therapeutic agents. Its reactive bromine atom is a gateway to introducing diverse substituents via established coupling chemistries, facilitating structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.

For effective sourcing, consider partnering with manufacturers directly. Based in China, many chemical manufacturers offer high-quality Boc-L-4-Bromophenylalanine at competitive prices, particularly for bulk quantities. This offers a dual benefit of cost savings and a more reliable supply chain. When evaluating suppliers, look for companies that demonstrate strong quality management systems, efficient logistics, and responsive customer service. Proactive communication regarding lead times and shipping can prevent unexpected project delays. Securing a sample for initial testing before committing to a large purchase is a prudent step for any procurement professional. Choosing a reliable supplier is investing in the success of your research and development endeavors.