For professionals in the pharmaceutical industry, securing a consistent supply of high-quality raw materials is paramount. N-(tert-Butoxycarbonyl)-L-phenylalanine, commonly known as Boc-L-Phenylalanine (CAS 13734-34-4), stands out as a critical amino acid derivative. Its role as a protected building block makes it indispensable in complex organic synthesis, particularly in the development of life-saving medications. This article aims to guide purchasing managers and R&D scientists in identifying reliable suppliers and understanding the key specifications for this vital intermediate.

Understanding Boc-L-Phenylalanine: Properties and Specifications

Boc-L-Phenylalanine is a derivative of the naturally occurring amino acid L-phenylalanine, featuring a tert-butyloxycarbonyl (Boc) protecting group on the amine nitrogen. This protection is crucial as it prevents unwanted reactions at the amino group during synthetic steps, allowing for selective modifications elsewhere in the molecule. Key specifications to look for when sourcing this compound include:

  • Purity: Typically, a purity of >99.0% (HPLC) is desired for pharmaceutical applications to ensure the efficacy and safety of the final drug product.
  • Appearance: It is generally supplied as a white powder or crystalline solid, which aids in handling and formulation.
  • Melting Point: A melting point within a defined range, such as 85-87°C, is an indicator of its purity and quality.
  • CAS Number: The Chemical Abstracts Service (CAS) number 13734-34-4 uniquely identifies this compound, essential for precise procurement.

The Critical Role in Pharmaceutical Synthesis

The primary application driving the demand for Boc-L-Phenylalanine is its use as a key intermediate in the synthesis of Bortezomib (CAS: 179324-69-7). Bortezomib is a proteasome inhibitor used in the treatment of multiple myeloma and mantle cell lymphoma. The precise structure and purity of Boc-L-Phenylalanine directly impact the yield and quality of the final Bortezomib API. Therefore, sourcing from a trusted manufacturer or supplier that can guarantee lot-to-lot consistency is crucial. For companies looking to buy Boc-L-Phenylalanine for such critical syntheses, understanding the manufacturing process and quality control measures of the supplier is vital.

Furthermore, Boc-L-Phenylalanine is widely used in peptide synthesis. The Boc group is a well-established protecting group in solid-phase and solution-phase peptide synthesis, enabling chemists to build complex peptide chains with high efficiency. Researchers and developers in drug discovery often require this intermediate for synthesizing novel peptide-based therapeutics or probes.

Navigating the Supply Chain: Manufacturer vs. Distributor

When seeking to purchase Boc-L-Phenylalanine, B2B buyers have the option to source directly from a manufacturer or through a distributor. Purchasing directly from a manufacturer in China or other established chemical production hubs often provides a better price and direct access to technical documentation and support. However, distributors can offer advantages in terms of lead time for smaller quantities or in regions where direct manufacturing presence is limited. Regardless of the channel, verifying the supplier's certifications, quality management systems (like ISO), and their ability to provide comprehensive Certificates of Analysis (CoA) is non-negotiable. Ensuring you are working with a reputable supplier that understands the stringent requirements of the pharmaceutical industry will streamline your procurement process and safeguard your project timelines.

In conclusion, Boc-L-Phenylalanine (CAS 13734-34-4) is more than just a chemical compound; it's a foundational element for innovation in pharmaceutical development. By focusing on purity, reliable supply, and strategic partnerships with qualified manufacturers, companies can ensure the successful progression of their research and production pipelines.