For procurement managers and R&D scientists in the pharmaceutical and biotech sectors, identifying reliable sources for critical chemical intermediates is a constant challenge. CAS 158171-14-3, known as Fmoc-Ser(HPO3Bzl)-OH, is one such compound that demands attention due to its pivotal role in phosphopeptide synthesis. This article serves as a guide for buyers looking to secure a consistent and high-quality supply of this essential material.

The primary challenge when purchasing specialty chemicals like CAS 158171-14-3 is ensuring both purity and consistent availability. This specific compound is a phosphorylated derivative of L-serine, protected with the Fmoc group and a benzyl ester on the phosphate. Its application is primarily in solid-phase peptide synthesis (SPPS) for creating peptides that mimic phosphorylated biological molecules. Therefore, even minor impurities can significantly impact synthesis yields and the fidelity of the final peptide. Buyers should prioritize sourcing from manufacturers that can provide a Certificate of Analysis (CoA) detailing purity levels, typically aiming for 98% or higher as stated for Fmoc-Ser(HPO3Bzl)-OH.

When engaging with potential suppliers, consider their location and logistical capabilities. For instance, many high-quality chemical intermediates are now manufactured in China. Companies like NINGBO INNO PHARMCHEM CO.,LTD. serve as both manufacturers and direct suppliers, offering competitive price points and a deep understanding of export processes. Their ability to manage the supply chain from production to delivery is crucial for businesses operating on tight research and development timelines.

Key information to request from a supplier includes:

  • Purity Specifications: Confirm the minimum purity (e.g., ≥98% by HPLC or TLC).
  • CAS Number Verification: Ensure the CAS number is correctly listed as 158171-14-3.
  • Batch Consistency: Inquire about their quality control processes to ensure batch-to-batch consistency.
  • Lead Times and MOQ: Understand the typical lead times for delivery and the Minimum Order Quantity (MOQ) to plan your procurement effectively.
  • Pricing Structure: Request detailed pricing, especially if you intend to buy in larger quantities or on a recurring basis.

Furthermore, it’s beneficial to work with suppliers who offer ongoing support. This might include technical data sheets, safety information, and responsiveness to inquiries. For CAS 158171-14-3, understanding its role in Fmoc SPPS and potential side reactions during deprotection can help buyers communicate their needs more precisely.

In conclusion, sourcing CAS 158171-14-3 requires a strategic approach that prioritizes quality, reliability, and value. By diligently evaluating potential suppliers and focusing on detailed product specifications, buyers can secure this vital reagent and ensure the success of their peptide synthesis endeavors. Reaching out for a quote from established manufacturers in China is often the most efficient first step.