In the intricate world of pharmaceutical synthesis, the quality and purity of raw materials are paramount. D-Phenylglycinamide, identified by its CAS number 6485-67-2, stands as a critical chiral intermediate, particularly noted for its role in the synthesis of antiviral drugs like Boceprevir. For procurement managers, R&D scientists, and formulation chemists, understanding the nuances of sourcing this compound is essential for ensuring the efficacy and safety of the final pharmaceutical products. This guide aims to illuminate the importance of high purity D-Phenylglycinamide and what to look for when partnering with a manufacturer or supplier.

D-Phenylglycinamide is a chiral amine, meaning it exists in distinct stereoisomeric forms. The D(-) enantiomer is often preferred for specific synthetic pathways due to its defined spatial arrangement, which directly influences the stereochemistry of the resulting molecule. The purity of D-Phenylglycinamide is not merely a technical specification; it directly impacts reaction yields, the formation of unwanted byproducts, and ultimately, the biological activity of the synthesized drug. Impurities, even in trace amounts, can lead to challenging purification steps, increased production costs, and potential regulatory hurdles.

When seeking to buy D-Phenylglycinamide, particularly from a manufacturer in China, several factors should be meticulously evaluated. Firstly, confirm the purity levels. Reputable suppliers will clearly state the minimum purity, often above 97% or even 98% for critical applications. Look for detailed Certificates of Analysis (CoA) that provide spectroscopic data (like NMR and HPLC) confirming the identity and purity of the compound. Secondly, inquire about the synthesis route and quality control measures employed by the manufacturer. Understanding how the compound is produced can offer insights into its potential impurity profile.

The “white to light yellow crystalline powder” appearance, as often described, is a visual indicator, but chemical analysis remains the definitive measure of quality. For R&D scientists, securing a consistent supply of this pharmaceutical intermediate is vital for uninterrupted research. Procurement managers often focus on the D-Phenylglycinamide price, balancing cost with the assurance of quality and reliability from their chosen supplier. It is crucial to remember that the cheapest option may not always be the most economical in the long run if it leads to production delays or quality issues.

Partnering with a well-established chemical supplier or manufacturer that specializes in pharmaceutical intermediates offers significant advantages. These partners can provide not only competitive pricing but also crucial technical support and regulatory documentation. For those looking to procure high-quality chiral amines, exploring options from reliable manufacturers is the first step towards a successful and efficient synthesis process. Always ensure your supplier can provide lot-specific CoAs and has robust quality assurance systems in place to meet your demanding requirements.