D-Phenylglycinamide, known by its CAS number 6485-67-2, is a compound of considerable interest in synthetic organic chemistry, particularly as a pharmaceutical intermediate. Its precise chemical structure and properties dictate its behavior in reactions and require specific handling and storage protocols to maintain its integrity and efficacy. This article outlines the essential chemical characteristics and handling guidelines for D-Phenylglycinamide, aimed at researchers and laboratory professionals.

The molecular formula of D-Phenylglycinamide is C8H10N2O, with a molecular weight of 150.18 g/mol. It typically presents as a white to light yellow crystalline powder. Key physical properties include a melting point in the range of 125-129°C and a solubility that is generally good in water (slightly soluble in heated aqueous acid and DMSO, methanol). The compound’s chirality is a defining feature, with the D(-) enantiomer being specifically utilized in many synthetic applications, such as in the synthesis of the Hepatitis C protease inhibitor, Boceprevir. Accurate specification of optical rotation, such as α20D -125±5, is crucial for confirming the correct enantiomer.

Regarding storage, D-Phenylglycinamide should be kept in a tightly closed container to prevent moisture absorption and contamination. The recommended storage conditions often include keeping it in a dark place under an inert atmosphere, ideally at temperatures between 2-8°C. These measures are crucial for preserving its chemical stability and preventing degradation over time. For procurement managers, understanding these requirements is key to ensuring that the product they purchase arrives and is stored correctly, maintaining its quality from manufacturer to end-user.

Safe handling practices are imperative when working with any chemical, including D-Phenylglycinamide. Standard laboratory precautions should be observed, such as wearing appropriate personal protective equipment (PPE), including gloves, eye protection, and lab coats. Proper ventilation should be ensured, and contact with skin, eyes, and inhalation of dust should be avoided. Safety Data Sheets (SDS) provided by the supplier offer comprehensive information on hazards, first-aid measures, and spill handling procedures. This information is vital for any laboratory or production facility looking to buy this compound.

In summary, D-Phenylglycinamide is a valuable chiral intermediate with specific chemical properties that necessitate careful handling and storage. By adhering to recommended protocols, researchers and manufacturers can ensure the quality, stability, and safe utilization of this compound in various synthetic applications. For those seeking to buy this essential chemical, consulting SDS and choosing reputable suppliers who provide clear handling guidelines is a critical step.