In the complex world of chemical synthesis, particularly for pharmaceutical intermediates, sourcing high-purity compounds is paramount. Pyridine-3-sulfonyl Chloride Hydrochloride (CAS 16133-25-8) stands out as a crucial building block, notably in the production of vonoprazan fumarate. For procurement managers and R&D scientists, understanding where to buy this chemical and what to look for in a supplier is key to successful project outcomes. This article serves as a guide for identifying reputable sources and ensuring you secure a reliable supply chain.

Why Pyridine-3-sulfonyl Chloride Hydrochloride is Critical

Pyridine-3-sulfonyl Chloride Hydrochloride (CAS 16133-25-8) is an organic compound valued for its specific reactivity, making it an indispensable intermediate in multi-step synthesis. Its primary recognized application is in the pharmaceutical industry, where it plays a vital role in creating Active Pharmaceutical Ingredients (APIs). The synthesis of vonoprazan fumarate, a potassium-competitive acid blocker, often involves this compound, underscoring its significance in developing modern therapeutics.

Key Specifications for Buyers

When purchasing Pyridine-3-sulfonyl Chloride Hydrochloride, several specifications are critical. Firstly, the purity level is of utmost importance. Typically, a purity of 98% or higher is sought after for pharmaceutical applications to ensure the efficacy and safety of the final drug product. The appearance is usually described as a white powder, which is a common form for such intermediates. Understanding the CAS number (16133-25-8) is also fundamental for accurate identification and sourcing.

Finding a Reliable Manufacturer and Supplier

Identifying a trustworthy manufacturer and supplier is crucial for securing a consistent and high-quality supply. Look for companies that specialize in fine chemicals and pharmaceutical intermediates. Key attributes to consider include:

  • Manufacturing Capabilities: Does the supplier have robust production facilities capable of producing the required quantities (kilos to tons)?
  • Quality Control: Does the manufacturer adhere to strict quality control protocols and provide Certificates of Analysis (CoA) for their products?
  • Supply Chain Stability: Can they guarantee timely delivery and maintain consistent product availability?
  • Technical Support: Do they offer technical assistance or custom synthesis services if needed?
  • Competitive Pricing: While quality is key, competitive pricing from a manufacturer is essential for cost-effectiveness.

Inquiry and Procurement Process

For procurement managers, initiating an inquiry with potential suppliers is the first step. Clearly state your requirements, including the CAS number, desired purity, quantity, and any specific packaging needs. Requesting a quotation will provide insights into pricing and lead times. Building a relationship with a reliable supplier, such as those offering Pyridine-3-sulfonyl Chloride Hydrochloride from China, can streamline your procurement process and ensure the uninterrupted flow of essential materials for your production needs.

Conclusion

Sourcing Pyridine-3-sulfonyl Chloride Hydrochloride (CAS 16133-25-8) requires diligence in identifying suppliers who prioritize quality, purity, and reliability. By focusing on these aspects and engaging with experienced manufacturers, businesses can secure the critical intermediates necessary for advancing their pharmaceutical research and production. When you need to buy this vital chemical, always ensure you are partnering with a reputable manufacturer to guarantee your project's success.