For procurement managers in the pharmaceutical and fine chemical industries, sourcing reliable, high-purity intermediates is paramount to successful product development and manufacturing. (S)-1-Cbz-3-pyrrolidinol (CAS: 100858-32-0) stands out as a crucial chiral building block, indispensable for the synthesis of complex molecules, particularly within drug discovery and agrochemical formulation. Understanding its specifications, applications, and the nuances of sourcing from reputable manufacturers is key to optimizing your supply chain and ensuring product quality.

Understanding (S)-1-Cbz-3-pyrrolidinol: The Core Specifications

(S)-1-Cbz-3-pyrrolidinol, with the molecular formula C12H15NO3 and a molecular weight of 221.25, is characterized by its pyrrolidine ring and a benzyloxycarbonyl (Cbz) protecting group. A critical attribute for its use in pharmaceutical synthesis is its chirality, allowing for precise stereochemical control in the formation of enantiomerically pure compounds. Procurement professionals must prioritize suppliers that guarantee high purity, typically exceeding 95% (GC), and provide detailed Certificates of Analysis (CoA). The melting point, usually within the range of 71-77 °C, is another important physical characteristic to verify.

Key Applications Driving Demand

The demand for (S)-1-Cbz-3-pyrrolidinol is primarily driven by its extensive use as a versatile intermediate in the synthesis of active pharmaceutical ingredients (APIs) and advanced agrochemicals. Its unique structure allows chemists to introduce diverse functional groups, facilitating the creation of complex molecular architectures. This compound is particularly valuable in the development of pharmaceuticals targeting neurological disorders, analgesics, and anti-inflammatory agents. For R&D scientists, its role in asymmetric synthesis is critical for achieving the specific stereochemistry required for drug efficacy and minimizing side effects.

Navigating the Procurement Process: Finding a Reliable Manufacturer and Supplier

When seeking to buy (S)-1-Cbz-3-pyrrolidinol, partnering with an experienced manufacturer and supplier is crucial. Look for companies that offer competitive pricing, consistent quality, and robust supply chain management. Sourcing from a leading manufacturer in China, for instance, can provide access to high-volume production capabilities and cost efficiencies. Key considerations include:

  • Purity Assurance: Always request and review the Certificate of Analysis (CoA) to confirm purity levels and enantiomeric excess.
  • Batch-to-Batch Consistency: Ensure the supplier can demonstrate consistent quality across different production batches, vital for reproducible synthesis.
  • Regulatory Compliance: Verify that the supplier adheres to relevant quality management systems (e.g., ISO) and can provide necessary documentation like MSDS and TDS.
  • Lead Times and Order Quantities: Confirm that the supplier can meet your required lead times and order volumes, whether for research quantities or bulk production.

By focusing on these aspects, procurement managers can effectively secure a stable supply of high-quality (S)-1-Cbz-3-pyrrolidinol, supporting their organization's innovation pipeline and manufacturing goals. For inquiries regarding pricing or to request a sample, contacting dedicated chemical suppliers is the first step.