For researchers and manufacturers involved in peptide synthesis, the quality of the building blocks is paramount. Fmoc-Glu-OtBu, also known by its CAS number 84793-07-7, is a critical protected amino acid derivative widely used in solid-phase peptide synthesis (SPPS). Sourcing this essential compound reliably and at a competitive price is a key challenge for many procurement managers and R&D scientists. This guide aims to shed light on where to buy high-quality Fmoc-Glu-OtBu and what factors to consider.

Understanding Fmoc-Glu-OtBu

Fmoc-Glu-OtBu, or Nα-Fmoc-L-glutamic acid α-tert-butyl ester, is characterized by its molecular formula C24H27NO6 and a molecular weight of approximately 425.47. It is typically supplied as a white to off-white solid. The 'Fmoc' (fluorenylmethyloxycarbonyl) group serves as a base-labile protecting group for the alpha-amino group, while the 'OtBu' (tert-butyl) ester protects the side-chain carboxyl group of glutamic acid. This dual protection strategy is fundamental in SPPS, allowing for selective deprotection and coupling steps in a controlled manner. Ensuring high purity, often specified as 98% by HPLC, is crucial to prevent side reactions and achieve the desired peptide sequence with high yield and accuracy.

Where to Buy Fmoc-Glu-OtBu: The Role of Chinese Manufacturers

China has emerged as a significant global hub for chemical manufacturing, including specialized intermediates like Fmoc amino acid derivatives. For businesses looking to buy Fmoc-Glu-OtBu, partnering with reputable Chinese manufacturers offers distinct advantages, including competitive pricing and scalable production capabilities. When seeking a supplier, it’s essential to look for companies with a proven track record in producing high-purity biochemicals for pharmaceutical and research applications. Key considerations include the manufacturer’s commitment to quality control, their ability to provide Certificates of Analysis (CoA), and their responsiveness to inquiries, especially for bulk orders or custom synthesis requirements.

Key Factors When Purchasing Fmoc-Glu-OtBu

  • Purity: Always verify the purity specifications, typically 98% by HPLC, to ensure reliable synthesis outcomes.
  • Supplier Reliability: Choose a manufacturer with a strong reputation for quality and consistent supply. Look for established companies that can provide necessary documentation.
  • Pricing and Pack Sizes: Compare prices across different suppliers and inquire about available pack sizes (e.g., 1g, 5g, 25g) to find the most cost-effective option for your needs. Bulk purchase pricing is often negotiable.
  • Technical Support and Lead Times: A good supplier will offer technical support and provide clear information on lead times for delivery.

For your peptide synthesis projects, securing a dependable source of Fmoc-Glu-OtBu is critical. By understanding the product's specifications and diligently researching potential suppliers, you can ensure you are purchasing a high-quality intermediate that meets your demanding research and production standards. If you are looking to purchase Fmoc-Glu-OtBu and require a reliable manufacturer in China, consider reaching out to NINGBO INNO PHARMCHEM CO.,LTD. for competitive pricing and exceptional product quality.