Fmoc-Glu-OtBu, identified by its CAS number 84793-07-7, is a fundamental protected amino acid that plays a pivotal role in modern peptide chemistry. As an integral part of the Fmoc strategy for peptide synthesis, its reliable supply and consistent quality are vital for researchers and manufacturers. This article delves into the key properties and applications of Fmoc-Glu-OtBu, highlighting why it remains a sought-after chemical intermediate.

Chemical Profile of Fmoc-Glu-OtBu

The chemical structure of Fmoc-Glu-OtBu combines L-glutamic acid with two key protecting groups: the base-labile N-terminal Fmoc group and the acid-labile tert-butyl ester on the gamma-carboxyl group. Its molecular formula is C24H27NO6, and its molecular weight is approximately 425.47. Typically supplied as a solid, it is crucial that the material meets stringent purity standards, often 98% by HPLC, to ensure successful coupling and minimal unwanted side reactions during peptide chain elongation. Understanding these specifications is key for any procurement manager or R&D scientist sourcing this compound.

Applications in Peptide Synthesis and Beyond

The primary application of Fmoc-Glu-OtBu is in solid-phase peptide synthesis (SPPS), where it serves as a protected building block for incorporating glutamic acid residues into peptide sequences. The tert-butyl ester protection on the side chain prevents unwanted reactions during peptide coupling and deprotection cycles. Following the assembly of the desired peptide chain, this protecting group can be readily removed under acidic conditions, revealing the free carboxylic acid functionality.

Beyond standard peptide synthesis, Fmoc-Glu-OtBu finds use in:

  • Development of Peptide-Based Therapeutics: As peptides gain prominence in drug discovery, intermediates like Fmoc-Glu-OtBu are essential for synthesizing novel drug candidates.
  • Bioconjugation: The side-chain carboxyl group, once deprotected, can be used for conjugation to other molecules, such as labels or targeting moieties.
  • Peptidomimetics: It can be incorporated into the synthesis of molecules that mimic the structure and function of natural peptides but possess improved stability or bioavailability.
  • Research and Development: From academic labs exploring new biochemical pathways to industrial R&D departments developing new materials, Fmoc-Glu-OtBu is a staple reagent.

For those looking to buy Fmoc-Glu-OtBu, choosing a reliable supplier that guarantees high purity and consistent quality is paramount. Companies like NINGBO INNO PHARMCHEM CO.,LTD. are dedicated to providing essential chemical intermediates like Fmoc-Glu-OtBu, catering to the needs of the global research and pharmaceutical industries. Inquiring about availability, pricing, and pack sizes will ensure you procure this vital building block efficiently.