For procurement managers and R&D scientists in the pharmaceutical industry, securing high-quality raw materials is paramount. L-2-Aminobutanamide Hydrochloride (CAS 7682-20-4) stands out as a critical chiral intermediate, primarily for the synthesis of Levetiracetam, a widely prescribed antiepileptic drug. Understanding its specifications, applications, and sourcing channels is key to efficient production and cost management. This guide aims to provide clarity for those looking to buy this essential pharmaceutical intermediate.

Understanding L-2-Aminobutanamide Hydrochloride

L-2-Aminobutanamide Hydrochloride is a white crystalline powder, characterized by its specific chemical properties. Key specifications often sought by purchasers include a high purity level, typically 99.0% or greater, and strict control over impurities, particularly the R-isomer, which must be kept below 0.5%. Its molecular formula is C4H11ClN2O, with a molecular weight of approximately 138.60 g/mol. The compound’s solubility in methanol and its specific rotation are also important parameters for quality assessment.

The primary utility of L-2-Aminobutanamide Hydrochloride lies in its role as a precursor for Levetiracetam. Levetiracetam is a third-generation antiepileptic drug known for its efficacy and favorable safety profile. As such, the demand for high-quality L-2-Aminobutanamide Hydrochloride remains consistently strong. Manufacturers that can guarantee consistent purity, chiral integrity, and reliable supply are highly valued partners.

Key Considerations for Procurement

When sourcing L-2-Aminobutanamide Hydrochloride, several factors should be prioritized:

  • Purity and Impurity Profile: Ensure the supplier provides a detailed Certificate of Analysis (CoA) that includes purity, loss on drying, residue on ignition, and chiral purity data. For Levetiracetam synthesis, controlling the R-isomer is critical.
  • Manufacturing Standards: Look for manufacturers who adhere to Good Manufacturing Practices (GMP) or similar quality management systems, ensuring the product is produced under controlled conditions.
  • Supply Chain Stability: A consistent and reliable supply is crucial for uninterrupted pharmaceutical production. Manufacturers with large-scale production capabilities and robust inventory management are preferable.
  • Regulatory Compliance: Confirm that the product documentation meets the regulatory requirements of your target markets.
  • Pricing and Packaging: Competitive pricing, especially for bulk orders, and appropriate packaging that maintains product integrity during transport and storage (often 25kg cardboard drums or as per customer requirements) are important logistical aspects.

Finding a Reliable Manufacturer/Supplier

For businesses looking to buy L-2-Aminobutanamide Hydrochloride, identifying reputable manufacturers and suppliers is the first step. China is a significant global hub for pharmaceutical intermediates. Companies specializing in chiral synthesis and API manufacturing are well-positioned to meet these demands. Seeking out suppliers who can offer technical support, transparent communication, and competitive pricing for bulk purchases is advisable. For example, engaging with established suppliers who list L-2-Aminobutanamide Hydrochloride on their product catalogs can streamline the initial inquiry process.

Ultimately, the successful procurement of L-2-Aminobutanamide Hydrochloride hinges on a thorough evaluation of potential suppliers, focusing on quality, reliability, and overall value. By prioritizing these aspects, pharmaceutical companies can ensure a stable supply of this vital intermediate, supporting the consistent production of Levetiracetam and contributing to patient care.