In the realm of advanced chemical synthesis, particularly for peptide-based therapeutics and research, the reliable procurement of high-quality starting materials is paramount. N-Boc-L-methionine, commonly referred to as Boc-Met-OH, is one such critical component. Its role as a protected amino acid derivative makes it an indispensable reagent for researchers and chemists engaged in constructing complex peptide sequences.

Boc-Met-OH is an L-amino acid derivative where the amine group of methionine is protected by the tert-butyloxycarbonyl (Boc) group. This protection strategy is fundamental to the widely used Boc Solid-Phase Peptide Synthesis (SPPS) methodology. By temporarily masking the reactive amine function, Boc-Met-OH allows for controlled sequential coupling with other amino acids, facilitating the precise elongation of peptide chains. Methionine itself, with its sulfur-containing side chain, is integral to the structure and function of many natural peptides and proteins, making its accurate incorporation essential.

For researchers, the primary considerations when looking to buy Boc-Met-OH are purity, availability, and price. The CAS number 2488-15-5 serves as a unique identifier for this chemical compound. Reputable manufacturers often provide detailed specifications, including a purity level typically exceeding 98%, and a Certificate of Analysis (CoA) to verify quality. The physical appearance is often described as a light yellow viscous liquid or crystal, with a specific melting point range (around 47-50°C). Understanding these specifications helps in selecting the appropriate grade for specific applications, from early-stage research to larger-scale synthesis.

Procuring Boc-Met-OH effectively requires a strategic approach to supplier selection. Many leading chemical manufacturers, particularly those based in China, are well-equipped to supply high-quality N-Boc-L-methionine. When evaluating suppliers, it is important to consider factors such as their production capacity, adherence to quality control standards, and customer service responsiveness. Competitive pricing is always a consideration, especially for bulk or wholesale purchases, but it should not overshadow the critical need for consistent product quality and reliable delivery. Many research institutions and pharmaceutical companies negotiate pricing based on annual volume requirements.

The effective utilization of Boc-Met-OH in research and development projects, from drug discovery to the creation of novel biomaterials, underscores its importance. Ensuring a stable and high-quality supply chain for this essential building block can significantly streamline laboratory workflows and accelerate project timelines. Therefore, investing time in identifying and partnering with trusted manufacturers and suppliers of Boc-Met-OH is a prudent strategy for any organization committed to excellence in chemical and peptide synthesis.