For professionals in the pharmaceutical and biotechnology sectors, sourcing high-quality chemical reagents is a fundamental aspect of successful research and development. Boc-Met-OH, also known as N-Boc-L-methionine, is a crucial protected amino acid derivative widely used in peptide synthesis. Understanding the key factors to consider when purchasing this compound can ensure optimal results and efficient project execution.

At its core, Boc-Met-OH is a derivative of the essential amino acid methionine. The tert-butyloxycarbonyl (Boc) group serves as a protective shield for the amino function of methionine, which is indispensable for controlled peptide chain elongation using the Boc Solid-Phase Peptide Synthesis (SPPS) methodology. Methionine itself, with its unique sulfur-containing side chain, often plays a vital role in the structure and biological activity of peptides. Therefore, the accurate and efficient incorporation of Boc-Met-OH is critical for synthesizing complex peptides and proteins.

When deciding to buy Boc-Met-OH, several technical specifications should be carefully reviewed. The CAS number, 2488-15-5, is the primary identifier for this chemical. The molecular formula is C10H19NO4S, and its molecular weight is approximately 249.3 g/mol. Suppliers typically provide detailed specifications regarding its physical form, often described as a light yellow viscous liquid or crystalline solid, and its melting point, which is usually between 47-50°C. Crucially, the purity of Boc-Met-OH is a major determinant of its effectiveness. Researchers should look for products with high purity levels, typically stated as >98%, to avoid interference with sensitive synthesis reactions.

Identifying a reliable supplier is paramount for consistent quality and availability. Many manufacturers and distributors, including those in China, offer Boc-Met-OH. When making a purchase decision, consider factors such as:

  • Purity: Ensure the product meets your specific research or manufacturing needs. Look for a detailed Certificate of Analysis (CoA).
  • Supplier Reputation: Research the supplier's track record, customer reviews, and overall reliability in the chemical supply chain.
  • Pricing and Quantity: Compare prices across different suppliers, especially for bulk or wholesale orders. Understand their pricing structures and potential discounts for larger quantities.
  • Delivery and Lead Times: Confirm the estimated delivery times, particularly if your project has tight deadlines.
  • Technical Support: A supplier that offers technical support can be invaluable in resolving any queries or issues.

The price of Boc-Met-OH can vary significantly based on these factors. However, the emphasis should always be on obtaining a high-quality product from a trustworthy source rather than solely focusing on the lowest price. Investing in quality Boc-Met-OH from a reputable manufacturer ensures the integrity of your synthetic processes and the reliability of your final peptide products.

In conclusion, Boc-Met-OH is a foundational reagent for peptide synthesis. By paying close attention to purity, supplier credentials, and pricing, researchers and procurement professionals can make informed decisions when purchasing this essential amino acid derivative, thereby supporting the success of their critical projects.