In the complex world of pharmaceutical manufacturing, the quality and availability of raw materials are paramount. For the production of Ofloxacin, a widely used fluoroquinolone antibiotic, one key intermediate is 1-(2,3-difluoro-6-nitrophenoxy)propan-2-one, identified by its CAS number 82419-32-7. Understanding the procurement of this compound is vital for research scientists, formulation chemists, and procurement managers aiming for efficient and compliant drug production.

The Role of 1-(2,3-Difluoro-6-nitrophenoxy)propan-2-one in Ofloxacin Synthesis

1-(2,3-Difluoro-6-nitrophenoxy)propan-2-one serves as a crucial building block in the multi-step synthesis of Ofloxacin. Its specific chemical structure, featuring difluoro and nitro groups on a phenoxy propan-2-one backbone, provides the necessary reactive sites for subsequent chemical transformations. The purity and consistent quality of this intermediate directly impact the yield and purity of the final Active Pharmaceutical Ingredient (API), Ofloxacin. Therefore, sourcing from a reputable manufacturer who guarantees high purity (typically 95% min) is a non-negotiable aspect of pharmaceutical quality control.

Procurement Best Practices for Pharmaceutical Intermediates

When looking to buy 1-(2,3-difluoro-6-nitrophenoxy)propan-2-one, pharmaceutical companies should consider several factors:

  • Supplier Reliability and Reputation: Seek out established chemical manufacturers and suppliers in regions known for quality chemical production, such as China. A supplier with a track record of consistent quality and adherence to international standards is essential. Look for manufacturers who can provide detailed Certificates of Analysis (CoA) and Safety Data Sheets (SDS).
  • Purity and Specifications: Verify that the product meets the required purity specifications (e.g., ≥95% min) and other physical properties like appearance (typically a yellow crystalline powder), melting point (40-45 °C), and density (1.41 g/cm³). These details are critical for successful integration into your synthesis process.
  • Supply Chain Stability: Ensure the supplier has a robust supply chain and can consistently deliver the required quantities, whether for pilot batches or commercial-scale production. Understanding lead times and minimum order quantities (MOQs) is also important for planning.
  • Regulatory Compliance: Confirm that the manufacturing process and documentation align with relevant regulatory requirements for pharmaceutical intermediates.

Why Choose a Chinese Manufacturer for Chemical Intermediates?

China has emerged as a global hub for chemical manufacturing, offering a vast array of intermediates at competitive prices. For materials like 1-(2,3-difluoro-6-nitrophenoxy)propan-2-one, partnering with a Chinese manufacturer can provide significant advantages in terms of cost-effectiveness and accessibility to large volumes. A well-vetted Chinese supplier can ensure that rigorous quality control measures are in place, making them a valuable partner in your global sourcing strategy. Investing in a direct relationship with a trusted manufacturer can streamline your procurement process and ensure you receive the best possible price.

In conclusion, for any pharmaceutical company involved in Ofloxacin production or related research, understanding the importance of high-quality 1-(2,3-difluoro-6-nitrophenoxy)propan-2-one (CAS: 82419-32-7) and knowing how to source it effectively is key. Prioritizing supplier reliability, product purity, and supply chain stability will ensure the success of your pharmaceutical development and manufacturing efforts.