For pharmaceutical manufacturers and R&D departments, the reliable sourcing of high-quality chemical intermediates is paramount. One such critical compound is 10-Propargyl-10-deazaaminopterin, more commonly known by its pharmaceutical name, Pralatrexate, and identified by CAS number 146464-95-1. This advanced antifolate agent plays a crucial role in the synthesis of active pharmaceutical ingredients (APIs) used in targeted cancer therapies, particularly for peripheral T-cell lymphoma (PTCL).

Understanding the nuances of sourcing Pralatrexate, including its specific chemical properties, potential applications, and market dynamics, is key to ensuring a stable and efficient supply chain. As a leading manufacturer and supplier of fine chemicals, particularly within China, we aim to provide insights for procurement managers and research scientists navigating this complex landscape. When looking to buy 10-Propargyl-10-deazaaminopterin, several factors should be considered to guarantee optimal results.

Understanding Pralatrexate (CAS 146464-95-1):

Pralatrexate is recognized for its potent inhibition of dihydrofolate reductase (DHFR), an enzyme essential for DNA synthesis. This makes it an effective agent in disrupting cancer cell proliferation. Its unique cellular uptake mechanism, via the reduced folate carrier (RFC), and extensive polyglutamation within cells contribute to its superior efficacy compared to older antifolates like methotrexate. This enhanced cellular retention and activity are critical attributes for its therapeutic application.

Key Considerations for Procurement:

When you are looking to purchase 10-Propargyl-10-deazaaminopterin, several aspects are crucial for a successful transaction:

  • Purity and Quality: The purity of Pralatrexate is non-negotiable for pharmaceutical applications. Manufacturers should seek suppliers who can provide Certificates of Analysis (CoA) detailing assay results (typically ≥98% or higher) and confirmation of minimal impurities. Reliable suppliers often adhere to stringent quality control measures, including ISO certifications.
  • Manufacturer Reputation: Partnering with a reputable 10-Propargyl-10-deazaaminopterin manufacturer, especially one based in China known for its robust chemical production capabilities, can ensure product consistency and reliability. Companies with established track records in API intermediate production are often preferred.
  • Supply Chain Stability: A consistent supply is vital for ongoing production. Understanding the manufacturer's production capacity and their ability to meet demand, even for bulk orders, is essential. Lead times for custom synthesis or large quantities should also be clarified.
  • Pricing and Quotation: The price of 10-Propargyl-10-deazaaminopterin can vary based on quantity, purity, and market conditions. Requesting detailed quotations for the required amounts is a standard practice. Understanding the payment terms and Incoterms (e.g., FOB, CFR) is also important.
  • Technical Support: A good supplier will offer technical support, including access to Safety Data Sheets (SDS) and assistance with regulatory documentation. This support can be invaluable for research and development teams.

Navigating the Market:

The global market for pharmaceutical intermediates is competitive. By focusing on manufacturers who offer transparent pricing, consistent quality, and robust technical support, businesses can secure their supply of essential compounds like Pralatrexate. Whether you are initiating a new drug development project or scaling up production, choosing the right supplier is a strategic decision that impacts product efficacy and market competitiveness.

For those seeking to buy 10-Propargyl-10-deazaaminopterin, engaging with established manufacturers and suppliers who understand the stringent requirements of the pharmaceutical industry is key. We are committed to providing high-quality Pralatrexate and supporting our clients' success through reliable supply and expert service.