In the global chemical supply chain, sourcing essential intermediates efficiently and reliably is a cornerstone of success for many industries, particularly pharmaceuticals and fine chemicals. Pyridine-3-sulfonyl Chloride Hydrochloride (CAS 16133-25-8) is one such critical compound. Known for its role as a pharmaceutical intermediate, particularly in the synthesis of vonoprazan fumarate, its availability from trusted manufacturers and suppliers is paramount. This article guides procurement specialists and R&D professionals on sourcing this vital chemical from China.

Why is Pyridine-3-sulfonyl Chloride Hydrochloride Important?

Pyridine-3-sulfonyl Chloride Hydrochloride (CAS 16133-25-8) is valued for its specific chemical properties, enabling it to act as a reactive intermediate in complex organic synthesis. Its structure allows for the introduction of the pyridinesulfonyl group, which is crucial for building specific molecular architectures found in many advanced chemical products. Its application as a precursor in the synthesis of vonoprazan fumarate, a widely used drug, highlights its significance in the pharmaceutical sector. This demand ensures a consistent need for high-quality, reliably sourced material.

Key Specifications for Buyers

When looking to buy Pyridine-3-sulfonyl Chloride Hydrochloride, procurement professionals should pay close attention to the following specifications:

  • Purity: A minimum purity of 98% is often required, especially for pharmaceutical use, ensuring the integrity of downstream synthesis.
  • Appearance: Typically described as a white powder, this physical characteristic aids in initial identification.
  • CAS Number: 16133-25-8 is the definitive identifier for this chemical.
  • Packaging: Appropriate packaging is essential to maintain stability and prevent degradation, often involving sealed drums or containers.
  • Manufacturer Reputation: A proven track record in chemical manufacturing and supply is a strong indicator of reliability.

Sourcing from China: Advantages and Considerations

China has emerged as a leading global hub for chemical manufacturing, offering significant advantages in terms of production capacity and cost-effectiveness. When sourcing Pyridine-3-sulfonyl Chloride Hydrochloride from Chinese manufacturers, consider:

  • Direct Manufacturer Engagement: Partnering directly with manufacturers often yields better pricing and more direct quality control.
  • Quality Assurance: Verify that suppliers provide Certificates of Analysis (CoA) and adhere to international quality standards.
  • Logistics and Export Capabilities: Ensure the manufacturer has experience in international shipping and export compliance.
  • Communication and Support: Look for suppliers who offer clear communication and responsive customer service to facilitate the procurement process.

Finding the Right Supplier

Identifying the right supplier involves research and due diligence. Look for companies that specialize in pharmaceutical intermediates and fine chemicals, have robust R&D capabilities, and can handle both small-scale (kilo) and large-scale (ton) orders. Establishing a long-term relationship with a trusted Chinese supplier can secure a consistent and high-quality supply of Pyridine-3-sulfonyl Chloride Hydrochloride for your ongoing projects.

Conclusion

Pyridine-3-sulfonyl Chloride Hydrochloride (CAS 16133-25-8) is a critical component in modern chemical and pharmaceutical synthesis. By focusing on purity, specifications, and partnering with reliable manufacturers and suppliers, particularly from China, businesses can ensure the efficient and high-quality procurement of this essential intermediate. This strategic approach supports innovation and production in critical industries.