In the intricate world of pharmaceutical manufacturing, sourcing high-quality intermediates is paramount. For companies involved in the synthesis of targeted cancer therapies, understanding the procurement of key building blocks like (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol (CAS 330156-50-8) is crucial. This article aims to guide procurement managers and R&D scientists on how to effectively find and purchase this essential chiral alcohol, emphasizing the importance of purity, reliable suppliers, and competitive pricing.

(R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is a specialized organic compound primarily utilized as a pivotal intermediate in the production of Crizotinib, a highly effective anaplastic lymphoma kinase (ALK) and ROS1 inhibitor used in treating certain types of non-small cell lung cancer. The precise stereochemistry of this alcohol is critical for the pharmacological activity of the final drug product, making its purity and optical integrity non-negotiable. Manufacturers and suppliers offering this compound must adhere to stringent quality control measures to ensure a product of >=98.0% purity and high enantiomeric excess.

When looking to buy (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol, it is essential to identify reputable manufacturers and suppliers. China has emerged as a significant hub for the production of pharmaceutical intermediates, offering a vast network of chemical companies. For procurement managers seeking the best value, exploring suppliers in China can lead to competitive pricing for bulk orders. Key considerations when selecting a supplier include their production capacity, quality assurance systems (e.g., ISO certifications, GMP compliance if applicable), and their ability to provide comprehensive documentation such as Certificates of Analysis (COA) and Material Safety Data Sheets (MSDS).

The price of (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol can vary based on purity, quantity, and the supplier's manufacturing scale. Bulk purchase inquiries often yield more favorable pricing per kilogram. It is advisable to request a quote from multiple established manufacturers to compare offerings. Companies like NINGBO INNO PHARMCHEM CO.,LTD. specialize in providing such advanced pharmaceutical intermediates, ensuring consistent supply and technical support. Their expertise in organic synthesis and commitment to quality make them a preferred partner for many pharmaceutical developers and contract manufacturing organizations (CMOs).

Beyond Crizotinib, this chiral alcohol may also be explored as a building block in the synthesis of other novel pharmaceutical compounds or in academic research focusing on stereoselective synthesis. The availability of (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol from reliable manufacturers with robust supply chains is fundamental to advancing drug discovery and development. Procurement professionals are encouraged to establish strong relationships with suppliers who can meet their long-term demands for this critical intermediate.

In conclusion, securing a stable and high-quality supply of (R)-1-(2,6-Dichloro-3-fluorophenyl)ethanol requires due diligence in supplier selection. Focusing on manufacturers in China known for their expertise in fine chemical synthesis, coupled with a thorough review of product specifications and pricing, will enable pharmaceutical companies to efficiently acquire this vital intermediate and drive their therapeutic development forward.