For chemists engaged in pharmaceutical synthesis, identifying and procuring high-quality intermediates is a critical first step in developing new drug candidates or optimizing existing manufacturing processes. (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine, known by its CAS number 196597-81-6, is a prime example of such an essential compound. Its significance lies in its role as a key chiral intermediate in the synthesis of Ramelteon, a melatonin receptor agonist used to treat insomnia. This article provides chemists with guidance on sourcing this vital chemical, emphasizing purity, supplier reliability, and application relevance.

Chemical Profile and Significance for Synthesis

(S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine (C13H17NO, MW: 203.280) is a colorless liquid with a high purity assay, typically ≥98.0%. The molecule features a complex indeno-furan core with an attached ethylamine chain, critically possessing the (S) stereochemical configuration. This chirality is paramount because it directly impacts the stereospecific binding of the final Ramelteon molecule to its target melatonin receptors, influencing therapeutic efficacy. Chemists often initiate their search with terms like 'buy (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine' or 'Ramelteon intermediate chemical supplier' to find suitable providers.

Understanding the specifications is key: the purity level must be high, and the stereochemical integrity must be maintained throughout the manufacturing process. When evaluating suppliers, chemists should look for detailed product specifications and ensure that any potential impurities are well-characterized and within acceptable limits for pharmaceutical synthesis.

Finding the Right Supplier: Key Criteria for Chemists

When a chemist needs to purchase (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine, the selection of a supplier involves several critical considerations:

  • Guaranteed Purity and Assay: The supplier must clearly state the purity (≥98.0%) and provide batch-specific Certificates of Analysis (CoA) that confirm this.
  • Stereochemical Control: Confirmation of the (S) configuration and the enantiomeric excess (ee) is crucial for effective synthesis.
  • Technical Data: Access to comprehensive technical data, including spectral information (NMR, IR) if available, aids in verifying the compound's identity and quality.
  • Supplier Reputation: A reputable supplier with a history of providing intermediates for pharmaceutical applications is essential. Searches for '(S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine price' can lead to comparing different manufacturers.
  • Custom Synthesis Capabilities: For specialized needs, inquiring about custom synthesis or modification services can be beneficial.

Our Expertise in Supplying Pharmaceutical Intermediates

As a specialized manufacturer and supplier, we are committed to providing chemists with the high-quality intermediates they need for their research and development efforts. Our production of (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine adheres to stringent quality control measures, ensuring both chemical and stereochemical purity. We understand the importance of reliable supply chains and offer competitive pricing, making us a preferred source for pharmaceutical chemists seeking this key Ramelteon precursor. Whether for small-scale laboratory use or larger pilot projects, we provide the materials needed to advance your synthesis goals.

Conclusion

The successful synthesis of pharmaceutical compounds like Ramelteon depends on the availability of high-purity, stereochemically defined intermediates. (S)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine is central to this process. Chemists are encouraged to partner with reliable suppliers who can guarantee quality and consistency. We invite you to explore our offerings and contact us for quotes or more information on how we can support your synthetic chemistry projects.