In the highly regulated and demanding world of pharmaceutical manufacturing, the sourcing of critical raw materials is paramount. (S)-(+)-3-Hydroxytetrahydrofuran (CAS 86087-23-2) stands out as a vital chiral intermediate, underpinning the synthesis of several life-saving medications. For procurement managers, R&D scientists, and formulation chemists, understanding how to effectively source this compound is key to successful drug development and production.

The Importance of (S)-(+)-3-Hydroxytetrahydrofuran in Drug Synthesis

This specific enantiomer of hydroxytetrahydrofuran is not just another chemical; it's a carefully crafted molecular building block. Its chirality is essential for creating drugs with precise stereochemical configurations, a requirement for optimal therapeutic efficacy and reduced side effects. Primary applications include its role as an intermediate in the synthesis of antiretroviral drugs for HIV/AIDS treatment, such as amprenavir and its prodrug fosamprenavir. Furthermore, it's a crucial component in the development of potent anticancer agents like empagliflozin and afatinib, and also finds utility in antiviral research and the preparation of other specialized APIs.

Key Considerations for Procurement

  • Purity: For pharmaceutical applications, exceptionally high purity is non-negotiable. Look for specifications of ≥99% purity, confirmed by analytical data such as GC. A reliable manufacturer will readily provide Certificates of Analysis (CoA) detailing assay, impurities, and other critical parameters.
  • Chiral Integrity: Ensuring the correct enantiomer is supplied is vital. Manufacturers should be able to guarantee the enantiomeric excess (ee) to ensure the correct stereochemistry is maintained throughout the synthesis process.
  • Supply Chain Reliability: Given the critical nature of the drugs derived from this intermediate, a stable and consistent supply is paramount. Partnering with a manufacturer that has robust production capabilities and a proven track record is essential to avoid disruptions.
  • Manufacturer vs. Trader: While many suppliers exist, sourcing directly from a reputable manufacturer, especially one based in China, can offer significant advantages in terms of price, quality control, and direct communication.
  • Pricing and Volume: For large-scale production, understanding the pricing structure and potential for volume discounts is crucial. Requesting a quote from multiple manufacturers can help identify the most cost-effective supplier.

Why Choose a Chinese Manufacturer?

China has emerged as a global powerhouse in the fine chemical and pharmaceutical intermediate sector. Many Chinese manufacturers offer not only competitive pricing due to economies of scale and efficient production processes but also possess advanced synthesis capabilities. When seeking to buy (S)-(+)-3-Hydroxytetrahydrofuran, opting for a trusted Chinese supplier like NINGBO INNO PHARMCHEM CO.,LTD. means accessing high-quality products backed by stringent quality control and a commitment to customer service. We understand the rigorous demands of the pharmaceutical industry and are equipped to meet them.

Making the Purchase Decision

When you need to purchase (S)-(+)-3-Hydroxytetrahydrofuran, consider the overall value proposition. This includes not just the price per kilogram, but also the guaranteed purity, the reliability of supply, and the technical support offered by the manufacturer. For companies looking for a dependable supplier of this essential pharmaceutical intermediate, exploring options from leading Chinese manufacturers is a strategic step. Contact us today to discuss your specific requirements and receive a competitive quote for your (S)-(+)-3-Hydroxytetrahydrofuran needs.