For procurement managers in the pharmaceutical and fine chemical industries, sourcing critical intermediates like Tert-Butyl Thiazol-4-ylcarbamate (CAS 1235406-42-4) is a strategic imperative. Ensuring a consistent supply of high-quality materials directly impacts research timelines, production efficiency, and the ultimate success of drug development pipelines. This guide focuses on the essential factors to consider when looking to buy this valuable compound.

Tert-Butyl Thiazol-4-ylcarbamate, also known by its IUPAC name tert-butyl N-(1,3-thiazol-4-yl)carbamate or as 4-(Boc-amino)thiazole, is a key building block in organic synthesis. Its molecular formula is C8H12N2O2S, with a molecular weight of approximately 200.26 g/mol. The compound typically presents as a white solid with a melting point in the range of 153-155 °C. Its utility stems from the presence of both a thiazole ring and a Boc-protected amine functional group, making it a versatile intermediate for creating more complex molecules, particularly within the pharmaceutical sector.

When considering the purchase of Tert-Butyl Thiazol-4-ylcarbamate, purity is paramount. Manufacturers often specify a purity level, and for pharmaceutical applications, a minimum of 97% is commonly required. Higher purities can be critical for reactions where impurities could lead to side products or affect downstream processes. Therefore, inquiring about the analytical methods used to determine purity (e.g., HPLC, GC) and requesting a Certificate of Analysis (CoA) is a standard practice for procurement professionals.

Beyond purity, understanding the supplier's capabilities is crucial. Are they a direct manufacturer or a distributor? A direct manufacturer can often provide more competitive pricing, better lead times, and more direct technical support. When looking for a reliable manufacturer, consider companies based in established chemical production hubs like China. These suppliers often have extensive experience in producing pharmaceutical intermediates at scale, offering both quality and cost-effectiveness. Exploring options for both small-scale research quantities and large bulk orders is advisable to ensure scalability as your project progresses.

Price is, of course, a significant factor. However, it should always be evaluated in conjunction with quality and reliability. Obtaining quotes from multiple suppliers is essential for price benchmarking. When requesting a quote for Tert-Butyl Thiazol-4-ylcarbamate, be specific about the quantity needed, desired purity, and packaging requirements. Some suppliers may offer discounts for larger orders, making it more economical to secure your supply for extended periods. For example, purchasing in quantities such as 25g, 100g, 500g, or bulk packages can significantly alter the per-unit cost.

The application of Tert-Butyl Thiazol-4-ylcarbamate primarily lies in its role as a pharmaceutical intermediate. It is instrumental in the synthesis of various drug candidates and active pharmaceutical ingredients (APIs). Its structural features allow for diverse chemical modifications, enabling medicinal chemists to explore new molecular architectures. Researchers also utilize it in the field of organic chemistry for developing novel synthetic methodologies and constructing complex heterocyclic systems.

In summary, for procurement managers seeking Tert-Butyl Thiazol-4-ylcarbamate (CAS 1235406-42-4), a strategic approach involving careful evaluation of purity, supplier reliability, pricing, and application potential is key. Partnering with a reputable manufacturer in China can provide a robust and cost-effective solution for your intermediate needs. Always prioritize clear communication and thorough due diligence to ensure a successful and sustainable supply chain.