For procurement managers and R&D scientists in the pharmaceutical industry, securing a reliable supply of key intermediates is paramount. One such critical compound is (2R,3R)-2,3-Bis[(4-methylbenzoyl)oxy]succinic acid compd. with (3R,4R)-N,4-dimethyl-1-(phenylmethyl)-3-piperidinamine, identified by CAS number 477600-71-8. This substance plays a pivotal role in the synthesis of Tofacitinib, a significant therapeutic agent. Understanding the nuances of sourcing this intermediate can significantly impact project timelines and costs.

When evaluating suppliers for CAS 477600-71-8, several factors come into play. The most crucial are purity and consistency. Pharmaceutical applications demand extremely high purity levels, often exceeding 95%. A reputable manufacturer will provide detailed certificates of analysis (CoA) to verify these specifications. Additionally, supply chain stability is a major concern. Buyers need assurance that the intermediate will be available consistently to avoid production delays. This is where partnering with established manufacturers and suppliers, particularly those based in China with robust production capabilities, can be advantageous.

The price of this pharmaceutical intermediate can vary based on quantity, purity, and supplier. For bulk purchases, buyers should always request detailed quotes from multiple manufacturers. Negotiating a favorable price for a Tofacitinib intermediate like CAS 477600-71-8 is often achievable through direct engagement with suppliers. Many Chinese manufacturers offer competitive pricing, especially for larger orders, and some may even provide sample quantities for initial testing. This makes exploring options from Chinese chemical suppliers a prudent step for any procurement manager.

Beyond quality and price, understanding the application of this intermediate is key. As a Tofacitinib intermediate, its precise chemical structure and stereochemistry are vital. Therefore, it is essential to confirm that the supplier can consistently deliver the correct enantiomers and diastereomers as required for the Tofacitinib synthesis pathway. For companies looking to buy this compound, thorough due diligence on the manufacturer and their production processes is highly recommended. Engaging with a knowledgeable supplier who can offer technical support and custom synthesis services can further streamline the procurement process for this specialized chemical.