Isopropyl 2-bromo-2-methylpropanoate (CAS: 51368-55-9) is a chemical compound that plays a crucial role in various industrial sectors, particularly in the realm of organic synthesis and pharmaceutical development. Understanding its synthesis, properties, and applications is vital for researchers, formulators, and procurement specialists. This article delves into the industrial significance of this compound, offering insights for those looking to procure it from reliable manufacturers and suppliers.

Understanding the Compound: Properties and Synthesis

With the chemical name Isopropyl 2-bromo-2-methylpropanoate, this substance is also known by synonyms such as 2-Bromo-2-methylpropionic Acid Isopropyl Ester. Its molecular formula is C7H13BrO2, and it has a molecular weight of approximately 209.08 g/mol. The compound is typically a colorless to pale yellow liquid, with a density of 1.26 g/cm³. Key physical characteristics include a boiling point of 168-170°C and a flash point of 56°C, indicating that careful handling and storage are necessary to ensure safety. The high purity, often specified as ≥99.0% by GC, along with low moisture content (≤0.1%), makes it suitable for demanding synthetic processes.

The synthesis of Isopropyl 2-bromo-2-methylpropanoate is primarily achieved through the esterification of 2-bromoisobutyric acid with isopropanol. This straightforward reaction, carried out under controlled conditions, allows for efficient production. For industrial-scale production, manufacturers often optimize this process to ensure high yields and purity, making it a cost-effective intermediate for downstream applications. The availability of raw materials and the efficiency of this synthesis route contribute to its accessibility for purchase from chemical suppliers.

Key Industrial Applications

The primary application of Isopropyl 2-bromo-2-methylpropanoate lies within the pharmaceutical industry. It serves as a critical intermediate in the synthesis of Active Pharmaceutical Ingredients (APIs). A notable example is its role in the production of Elafibranor, a medication used in the treatment of certain liver conditions. The bromine atom on the molecule is a reactive site that facilitates various synthetic transformations, allowing chemists to build complex molecular architectures required for therapeutic compounds. This makes it an indispensable component for pharmaceutical R&D and manufacturing.

Beyond pharmaceuticals, its utility extends to other areas of fine chemical synthesis. Its reactive nature makes it a valuable building block for creating a wide range of organic molecules used in specialty chemicals, agrochemicals, and materials science. As industries continue to innovate and demand more complex compounds, intermediates like Isopropyl 2-bromo-2-methylpropanoate will remain essential.

Procurement Considerations: Finding the Right Supplier

For businesses looking to buy this compound, sourcing from reliable manufacturers and suppliers, particularly those based in China, is often the most practical approach due to competitive pricing and production capacity. When evaluating potential suppliers, it’s important to consider their experience, quality control measures, and ability to provide consistent supply. Checking for certifications, understanding their packaging options (e.g., 250 kg drums), and requesting sample batches for testing are all critical steps in the procurement process. Ensuring a stable supply chain is paramount for maintaining continuous production cycles and meeting market demands.

In summary, Isopropyl 2-bromo-2-methylpropanoate is a valuable chemical intermediate with significant industrial applications, especially in pharmaceutical synthesis. Its efficient production and high purity make it a sought-after compound. By understanding its properties and procurement considerations, businesses can effectively source this vital material to support their chemical synthesis needs.