The intricate world of organic synthesis relies on a diverse array of building blocks and intermediates. Among these, 6-Chlorouracil (CAS 4270-27-3) holds a prominent position, particularly within the pharmaceutical sector. Its unique chemical structure and reactivity make it an indispensable component in the multi-step synthesis of various complex molecules, including important APIs.

The Chemical Profile of 6-Chlorouracil

6-Chlorouracil, with its chemical formula C4H3ClN2O2 and a molecular weight of 146.53 g/mol, is a derivative of uracil, a pyrimidine base. It is typically provided as a white to off-white crystalline powder with a high purity, often specified at 99%. This purity is crucial as it directly impacts the efficiency and outcome of subsequent synthetic steps. Its primary function is that of a pharmaceutical intermediate, serving as a starting material or a key component in the synthesis pathways of drugs.

Applications in Pharmaceutical Synthesis

The most notable application of 6-Chlorouracil as an intermediate is in the synthesis of alogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor used for treating type 2 diabetes. The chlorine atom at the 6th position of the uracil ring offers a reactive site that can be readily functionalized through various chemical reactions, such as nucleophilic substitution. This allows chemists to attach different side chains and create the complex molecular architecture required for therapeutic efficacy. Beyond alogliptin, 6-Chlorouracil can be a precursor for other heterocyclic compounds with potential biological activity, making it a valuable asset in drug discovery laboratories.

Sourcing 6-Chlorouracil for Your Synthesis Needs

For research scientists and process chemists, securing a reliable supply of high-quality 6-Chlorouracil is essential. When you look to buy 6-chlorouracil, it's important to partner with manufacturers who specialize in pharmaceutical intermediates. Companies that can provide a consistent 99% purity assay and offer competitive pricing are ideal. For those needing to purchase 6-chlorouracil, sourcing from established chemical suppliers in regions like China, which have robust manufacturing capabilities, can be advantageous. Many of these suppliers offer bulk packaging and detailed product specifications, including CAS 4270-27-3, to meet research and development demands.

If your work involves organic synthesis, particularly in the pharmaceutical realm, understanding the importance and availability of intermediates like 6-Chlorouracil is key. We are a dedicated 6-chlorouracil manufacturer and supplier, committed to providing the high-quality materials needed for successful synthesis. We invite you to get a quote and explore how we can support your next project.