For organic chemists and researchers, understanding the synthesis and reactivity of key intermediates is fundamental to successful research and development. 5-Bromo-2-methoxypyridine (CAS: 13472-85-0) is a prime example of such an intermediate, prized for its versatility in constructing complex organic molecules. Its utility spans across pharmaceutical synthesis, agrochemical development, and materials science. As a leading manufacturer and supplier, we aim to provide insight into this valuable compound and its procurement.

The synthesis of 5-Bromo-2-methoxypyridine typically involves the nucleophilic substitution of a halogen atom on a pyridine ring with a methoxide source. A common and efficient method starts from 2,5-dibromopyridine. In this process, 2,5-dibromopyridine is reacted with sodium methoxide (or a similar methoxide salt) in methanol under reflux conditions. This reaction selectively replaces the bromine atom at the 2-position with a methoxy group, yielding 5-Bromo-2-methoxypyridine with high yields, often around 98%. This method, detailed in various patents and chemical literature, is a standard industrial route when you need to buy this intermediate.

The reactivity of 5-Bromo-2-methoxypyridine is largely dictated by its two key functional groups: the bromine atom and the methoxy-substituted pyridine ring. The bromine atom at the 5-position is highly amenable to electrophilic aromatic substitution and, more importantly, a wide array of metal-catalyzed cross-coupling reactions. These include:

  • Suzuki-Miyaura Coupling: Reacting with boronic acids or esters to form new carbon-carbon bonds, widely used in drug discovery.
  • Sonogashira Coupling: Coupling with terminal alkynes to introduce alkynyl groups.
  • Heck Reaction: Coupling with alkenes.
  • Buchwald-Hartwig Amination: Forming carbon-nitrogen bonds by reacting with amines.

The methoxy group can influence the electronic density of the pyridine ring, potentially affecting the regioselectivity of further reactions. It can also be cleaved under specific conditions to reveal a hydroxyl group, offering another avenue for functionalization. This rich reactivity profile makes 5-Bromo-2-methoxypyridine a chemist’s go-to intermediate.

Sourcing this intermediate requires attention to purity and reliable supply. Our facility in China is equipped to produce 5-Bromo-2-methoxypyridine at high purity (≥99.0%), ensuring that your synthesis reactions proceed smoothly. We understand the importance of competitive pricing and dependable delivery for researchers and manufacturers alike. If you are looking to buy 5-Bromo-2-methoxypyridine, consider our offerings and request a quote. Our commitment is to support your chemical endeavors with quality products and excellent service.