Tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate: A Key Pharmaceutical Building Block
In the intricate world of pharmaceutical synthesis, the quality and availability of chemical intermediates are of paramount importance. Tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate (CAS: 877399-50-3) has established itself as a crucial building block, underpinning the development of sophisticated pharmaceutical agents. Its unique chemical structure, featuring a brominated pyrazole ring linked to a protected piperidine moiety, makes it an indispensable component for chemists engaged in advanced drug discovery and development.
This compound is widely recognized for its role as a key intermediate in the synthesis of Crizotinib, a groundbreaking targeted therapy for specific subtypes of non-small cell lung cancer. The efficacy of Crizotinib relies on its precise molecular architecture, which is meticulously assembled using high-purity intermediates like tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate. The compound’s high purity, typically u226598.0%, ensures that the final API meets strict quality standards, free from detrimental impurities that could affect its safety or efficacy.
As a versatile intermediate, it facilitates complex chemical transformations. The bromopyrazole group serves as an excellent substrate for cross-coupling reactions, allowing for the introduction of various substituents and the extension of molecular complexity. The tert-butyl carbamate (Boc) protecting group on the piperidine nitrogen can be easily cleaved, enabling further functionalization of the piperidine ring. This dual reactivity makes it an ideal starting material for constructing diverse heterocyclic frameworks, which are frequently found in biologically active molecules.
NINGBO INNO PHARMCHEM CO.,LTD., a prominent manufacturer and supplier in China, specializes in providing high-quality pharmaceutical building blocks. Our commitment to excellence ensures that tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate is produced under rigorous quality control measures. This dedication guarantees that researchers and manufacturers can reliably buy this essential intermediate, confident in its consistency and purity for their critical synthesis needs.
The applications of this bromopyrazole derivative extend beyond oncology. It is a valuable tool for medicinal chemists exploring new therapeutic avenues. By utilizing this intermediate, scientists can efficiently synthesize novel compounds for screening against a wide range of biological targets, thereby accelerating the drug discovery pipeline. Its availability as a standard chemical building block simplifies the experimental design and execution for many research projects.
In conclusion, tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate is a vital component in the modern pharmaceutical synthesis arsenal. Its role as a key building block for drugs like Crizotinib, coupled with its versatile chemical reactivity, highlights its importance. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying this high-quality intermediate, supporting the global effort to develop innovative medicines.
This compound is widely recognized for its role as a key intermediate in the synthesis of Crizotinib, a groundbreaking targeted therapy for specific subtypes of non-small cell lung cancer. The efficacy of Crizotinib relies on its precise molecular architecture, which is meticulously assembled using high-purity intermediates like tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate. The compound’s high purity, typically u226598.0%, ensures that the final API meets strict quality standards, free from detrimental impurities that could affect its safety or efficacy.
As a versatile intermediate, it facilitates complex chemical transformations. The bromopyrazole group serves as an excellent substrate for cross-coupling reactions, allowing for the introduction of various substituents and the extension of molecular complexity. The tert-butyl carbamate (Boc) protecting group on the piperidine nitrogen can be easily cleaved, enabling further functionalization of the piperidine ring. This dual reactivity makes it an ideal starting material for constructing diverse heterocyclic frameworks, which are frequently found in biologically active molecules.
NINGBO INNO PHARMCHEM CO.,LTD., a prominent manufacturer and supplier in China, specializes in providing high-quality pharmaceutical building blocks. Our commitment to excellence ensures that tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate is produced under rigorous quality control measures. This dedication guarantees that researchers and manufacturers can reliably buy this essential intermediate, confident in its consistency and purity for their critical synthesis needs.
The applications of this bromopyrazole derivative extend beyond oncology. It is a valuable tool for medicinal chemists exploring new therapeutic avenues. By utilizing this intermediate, scientists can efficiently synthesize novel compounds for screening against a wide range of biological targets, thereby accelerating the drug discovery pipeline. Its availability as a standard chemical building block simplifies the experimental design and execution for many research projects.
In conclusion, tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate is a vital component in the modern pharmaceutical synthesis arsenal. Its role as a key building block for drugs like Crizotinib, coupled with its versatile chemical reactivity, highlights its importance. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying this high-quality intermediate, supporting the global effort to develop innovative medicines.
Perspectives & Insights
Agile Reader One
“The efficacy of Crizotinib relies on its precise molecular architecture, which is meticulously assembled using high-purity intermediates like tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylate.”
Logic Vision Labs
“0%, ensures that the final API meets strict quality standards, free from detrimental impurities that could affect its safety or efficacy.”
Molecule Origin 88
“The bromopyrazole group serves as an excellent substrate for cross-coupling reactions, allowing for the introduction of various substituents and the extension of molecular complexity.”